This is an H2 congenic strain in which two H2 alleles were transferred from a non-inbred Swiss mouse to the A/WySn strain.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Not Applicable | H2 | histocompatibility-2, MHC |
Allele Type | Gene Symbol | Gene Name |
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Not Applicable (Not Applicable) | H2-T18 | histocompatibility 2, T region locus 18 |
The H2s haplotype, including H2-T18b , was transferred by George Snell from a non-inbred Swiss mouse to the A/WySn strain background by 14 generations of backcrossing (Klein 1968, p. 804).
Allele Name | b variant |
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Allele Type | Not Applicable (Not Applicable) |
Allele Synonym(s) | TL-; Tlab |
Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 |
Gene Synonym(s) | |
Strain of Origin | Not Applicable |
Chromosome | 17 |
Molecular Note | The allele H2-T18b determines absence of the antigen (TL-) and occurs in strains C57BL/6, AKR, C3H/An, and many others. |
The Jackson Laboratory has not developed a genotyping protocol for H2 haplotypes. The following reference may helpful: Saha BK. J Immunol Meth 1996 Jul 17;194(1):77-83. (PMID: 8690943). Alternatively, haplotype-specific antibodies can be used with FACS.
When using the A.SW-H2s H2-T18b/SnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000471 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Inbred, 1 pair minimum will be supplied |
Frozen Mouse Embryo | A.SW-H2<s> H2-T18<b>/SnJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | A.SW-H2<s> H2-T18<b>/SnJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | A.SW-H2<s> H2-T18<b>/SnJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | A.SW-H2<s> H2-T18<b>/SnJ Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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