A.SW-H2^s H2-T18^b/SnJ

Stock number: 000471
Strain synonyms: A.SW
Research areas: Immunology, Inflammation and Autoimmunity Research

Description

This is an H2 congenic strain in which two H2 alleles were transferred from a non-inbred Swiss mouse to the A/WySn strain.

Development

The H2^s haplotype, including H2-T18^b , was transferred by George Snell from a non-inbred Swiss mouse to the A/WySn strain background by 14 generations of backcrossing (Klein 1968, p. 804).

Allele

Symbol: H2^s
Name: s variant
MGI accession ID: MGI:3579325
Generation method: Not Applicable
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Marker synonyms: H-2; MHC-II
Chromosome: 17
Strain of origin: Not Applicable
General note: The s variant has been observed in the following strains: SJL/J, A.SW, B10.S

Allele

Symbol: H2-T18^b
Name: b variant
MGI accession ID: MGI:4820508
Generation method: Not Applicable
Attributes: Not Applicable
Synonyms: TL^-; Tla^b
Marker symbol: H2-T18
Marker name: histocompatibility 2, T region locus 18
Marker synonyms: H-2T18; TL Ag; Tla
Chromosome: 17
Strain of origin: Not Applicable
Molecular note: The allele H2-T18^b determines absence of the antigen (TL^-) and occurs in strains C57BL/6, AKR, C3H/An, and many others.