These mice carry the PL-derived H2u region and thymus leukemia (TL) antigen gene and are useful in dissecting the role of MHC versus non-MHC genes in producing aberrant immunophenotypes.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Not Applicable | H2 | histocompatibility-2, MHC |
Allele Type | Gene Symbol | Gene Name |
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Not Applicable | H2-T18 | histocompatibility 2, T region locus 18 |
Marker Symbol | Marker Name | |
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H2 | histocompatibility-2, MHC | |
H2-T18 | histocompatibility 2, T region locus 18 |
These mice carry the H2u region and Class 1b T18a (thymus leukemia (TL) antigen) gene derived from the PL/J genetic background. C57BL/6 and C57BL/10 mice carry a natural deletion of the H2-T18 gene. This antigen is expressed by intestinal epithelial cells and helps maintain intraepithelial CD8+ lymphocyte (IEL) functions. These mice may be useful when studying inflammation associated with inflammatory bowel diseases (IBD) ulcerative colitis and Crohn's disease.
Allele Name | a variant |
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Allele Type | Not Applicable |
Allele Synonym(s) | Tlaa |
Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 |
Gene Synonym(s) | |
Strain of Origin | Not Applicable |
Chromosome | 17 |
Molecular Note | The allele H2-T18a determines presence of the antigenic specificities TL.1, 2, 3, 5, 6, 7 and occurs in strains A, C57BR, C58, SJL, and others. |
Marker Synonym(s) | |
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Chromosome(s) | 17 |
Marker Synonym(s) | |
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Chromosome(s) | 17 |
The Jackson Laboratory has not developed a genotyping protocol for H2 haplotypes. The following reference may helpful: Saha BK. J Immunol Meth 1996 Jul 17;194(1):77-83. (PMID: 8690943). Alternatively, haplotype-specific antibodies can be used with FACS.
When maintaining a live colony, homozygous mice may be bred together.
When using the B10.PL mouse strain in a publication, please cite the originating article(s) and include JAX stock #000458 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous for H2<u>, Homozygous for H2-T18<a>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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