B10.PL-H2^u H2-T18^a/(73NS)SnJ

Stock number: 000458
Product name: B10.PL
Research areas: Immunology, Inflammation and Autoimmunity Research

Description

These mice carry the PL-derived H2^u region and thymus leukemia (TL) antigen gene and are useful in dissecting the role of MHC versus non-MHC genes in producing aberrant immunophenotypes.

Detailed description

These mice carry the H2^u region and Class 1b T18^a (thymus leukemia (TL) antigen) gene derived from the PL/J genetic background. C57BL/6 and C57BL/10 mice carry a natural deletion of the H2-T18 gene. This antigen is expressed by intestinal epithelial cells and helps maintain intraepithelial CD8⁺ lymphocyte (IEL) functions. These mice may be useful when studying inflammation associated with inflammatory bowel diseases (IBD) ulcerative colitis and Crohn's disease.

Development

PL/J (Stock No. 000680) was crossed with C57BL/10SnJ (Stock No. 000666) for at least 10 generations with selection for PL-derived H2^u and H2-T18^a (thymus leukemia (TL) antigen) at each generation.

Allele

Symbol: H2^u
Name: u variant
MGI accession ID: MGI:3834991
Generation method: Not Applicable
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Marker synonyms: H-2; MHC-II
Chromosome: 17
Strain of origin: Not Applicable
General note: The q variant has been observed in the PL/J strain.

Allele

Symbol: H2-T18^a
Name: a variant
MGI accession ID: MGI:4820507
Generation method: Not Applicable
Synonyms: Tla^a
Marker symbol: H2-T18
Marker name: histocompatibility 2, T region locus 18
Marker synonyms: H-2T18; TL Ag; Tla
Chromosome: 17
Strain of origin: Not Applicable
Molecular note: The allele H2-T18^a determines presence of the antigenic specificities TL.1, 2, 3, 5, 6, 7 and occurs in strains A, C57BR, C58, SJL, and others.