B10.RIII-H2^r H2-T18^b/(71NS)SnJ

Stock number: 000457
Product name: B10.RIII
Research areas: Immunology, Inflammation and Autoimmunity Research

Description

This congenic strain develops chronic and relapsing experimental autoimmune encephalomyelitis (EAE) after immunization with myelin basic protein (MBP). Susceptibility is associated with the major histocompatibility complex (MHC) allele, H2^r, the T cell receptor V β8 chain, and other non MHC loci. This strain also is susceptible to induction of collagen-induced arthritis. This congenic strain has been used for numerous immunological studies.

Development

This congenic resistant stain was developed by Dr. George Snell and Dr. Marianna Cherry in the 1960's. The RIII strain was crossed to C57BL/10Sn mice and progeny were backcrossed to C57BL/10Sn mice for a total of 8 backcross generations. Progeny were selected for each backcross by serotyping with anti-H2^r antisera.

Approximate pedigree generation numbers and dates: N8F77 October 1992, N8F117 November 2005, N8F128 January 2010, N8F138 September 2013, N8F142 August 2014, N9 April 2016, N10 August 2017, N11F3 April 2018.

Allele

Symbol: H2^r
Name: r haplotype
MGI accession ID: MGI:5780884
Generation method: Not Applicable
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Chromosome: 17
Strain of origin: RIII

Allele

Symbol: H2-T18^b
Name: b variant
MGI accession ID: MGI:4820508
Generation method: Not Applicable
Attributes: Not Applicable
Marker symbol: H2-T18
Marker name: histocompatibility 2, T region locus 18
Chromosome: 17
Strain of origin: Not Applicable
Molecular note: The allele H2-T18^b determines absence of the antigen (TL^-) and occurs in strains C57BL/6, AKR, C3H/An, and many others.

Allele

MGI accession ID: MGI:95950
Marker symbol: H2-T18
Marker name: histocompatibility 2, T region locus 18
Chromosome: 17

Allele

MGI accession ID: MGI:95894
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Chromosome: 17