This congenic strain develops chronic and relapsing experimental autoimmune encephalomyelitis (EAE) after immunization with myelin basic protein (MBP). Susceptibility is associated with the major histocompatibility complex (MHC) allele, H2r, the T cell receptor V β8 chain, and other non MHC loci. This strain also is susceptible to induction of collagen-induced arthritis. This congenic strain has been used for numerous immunological studies.
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Allele Type | Gene Symbol | Gene Name |
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Not Applicable (Not Applicable) | H2-T18 | histocompatibility 2, T region locus 18 |
Allele Type | Gene Symbol | Gene Name |
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Not Applicable | H2 | histocompatibility-2, MHC |
Marker Symbol | Marker Name | |
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H2 | histocompatibility-2, MHC | |
H2-T18 | histocompatibility 2, T region locus 18 |
This congenic resistant stain was developed by Dr. George Snell and Dr. Marianna Cherry in the 1960's. The RIII strain was crossed to C57BL/10Sn mice and progeny were backcrossed to C57BL/10Sn mice for a total of 8 backcross generations. Progeny were selected for each backcross by serotyping with anti-H2r antisera.
Allele Name | b variant |
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Allele Type | Not Applicable (Not Applicable) |
Allele Synonym(s) | TL-; Tlab |
Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 |
Gene Synonym(s) | |
Strain of Origin | Not Applicable |
Chromosome | 17 |
Molecular Note | The allele H2-T18b determines absence of the antigen (TL-) and occurs in strains C57BL/6, AKR, C3H/An, and many others. |
Marker Synonym(s) | |
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Chromosome(s) | 17 |
Marker Synonym(s) | |
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Chromosome(s) | 17 |
Wean-aged mice may show signs of barbering that include whisker picking. Affected mice typically regrow whiskers within two weeks after weaning.
When using the B10.RIII mouse strain in a publication, please cite the originating article(s) and include JAX stock #000457 in your Materials and Methods section.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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