This C3H congenic strain carries the H2j haplotype from the JK/StSn strain.
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable (Not Applicable) | H2-T18 | histocompatibility 2, T region locus 18 |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable (Not Applicable) | H2 | histocompatibility-2, MHC |
Marker Symbol | Marker Name | |
---|---|---|
H2 | histocompatibility-2, MHC | |
H2-T18 | histocompatibility 2, T region locus 18 |
The H2 haplotype for this strain was earlier designated as H2ar, but later determined to be H2j.
This C3H congenic strain carries the H2j haplotype from the JK/StSn strain.
This is a “Congenic Resistant” strain of mice developed by George D. Snell with Marianna Cherry in their studies of histocompatibility. [Snell, G.D. 1978. In Origins of Inbred Mice (H.C. Morse III, ed.). Academic Press, New York.]
The strain was backcrossed the equivalent of 8 generations to C3H/HeDiSn before being maintained by sib matings. Embryos were cryopreserved in 1990, 1998, and 2006.
Allele Name | b variant |
---|---|
Allele Type | Not Applicable (Not Applicable) |
Allele Synonym(s) | TL-; Tlab |
Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 |
Gene Synonym(s) | |
Strain of Origin | Not Applicable |
Chromosome | 17 |
Molecular Note | The allele H2-T18b determines absence of the antigen (TL-) and occurs in strains C57BL/6, AKR, C3H/An, and many others. |
Allele Name | histocompatibility-2, MHC; j variant |
---|---|
Allele Type | Not Applicable (Not Applicable) |
Allele Synonym(s) | |
Gene Symbol and Name | H2, histocompatibility-2, MHC |
Gene Synonym(s) | |
Strain of Origin | various |
Chromosome | 17 |
Molecular Note | This histocompatibility haplotype was identified in inbred donors I/St, JK/St, and WB/Re and has a unique j specificity in H2-K through H2-Ebeta then H2-Db, H2-Lb, Qa2a, H2-T18b, and Qa1b. |
Marker Synonym(s) | |
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Chromosome(s) | 17 |
Marker Synonym(s) | |
---|---|
Chromosome(s) | 17 |
When using the C3H.JK/Sn mouse strain in a publication, please cite the originating article(s) and include JAX stock #000441 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for H2<j>, Homozygous for H2-T18<b>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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