C3.SW-H2^b/SnJ

Stock number: 000438
Strain synonyms: C3H.H2b
Research areas: Diabetes and Obesity Research, Immunology, Inflammation and Autoimmunity Research

Description

Male mice from the C3.SW-H2^b/SnJ congenic strain are predisposed to maturity-onset impairment of glucose tolerance and hyperinsulinemia with some mice exhibiting hyperglycemia, and they are susceptible to the diabetogenic effects of multiple low doses of streptozotocin. In addition these mice have been used in many different immunological studies.

Detailed description

Male mice from the C3.SW-H2^b/SnJ congenic strain are predisposed to maturity-onset impairment of glucose tolerance and hyperinsulinemia with some mice exhibiting hyperglycemia. Symptoms occur much later, between 5 and 8 months of age, than most of the single gene obese and diabetic strains. In addition, male mice are susceptible to the diabetogenic effects of multiple low doses of streptozotocin (40 mg/kg BW.day X 5).

Development

This strain was created, beginning in 1948, by George Snell by transferring the H2^b haplotype from a mouse of an outbred Swiss stock onto the C3H/HeDiSn inbred strain by 11 rounds of backcross-intercross breeding (Snell 1958).

Allele

Symbol: H2^b
Name: b variant
MGI accession ID: MGI:3579319
Generation method: Not Applicable
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Chromosome: 17
Strain of origin: Not Applicable
General note: The b variant has been observed in the following strains: C57BL/10, C57BL/10SnJ, BXSB/MpJ, C57BL/6J, C57L/J, LP/J, 129P3/J, 129P1/ReJ.

Allele

Symbol: B2m^a
Name: a variant
MGI accession ID: MGI:6357680
Generation method: Spontaneous
Attributes: Not Applicable
Marker symbol: B2m
Marker name: beta-2 microglobulin
Chromosome: 2
Strain of origin: multiple strains
Molecular note: The a variant is slightly slower running on SDS PAGE and was found to have an aspartic acid at amino acid position 85. This allele is found in A, BALB/c, LP and most other strains.