Male mice from the C3.SW-H2b/SnJ congenic strain are predisposed to maturity-onset impairment of glucose tolerance and hyperinsulinemia with some mice exhibiting hyperglycemia, and they are susceptible to the diabetogenic effects of multiple low doses of streptozotocin. In addition these mice have been used in many different immunological studies.Read More +
Male mice from the C3.SW-H2b/SnJ congenic strain are predisposed to maturity-onset impairment of glucose tolerance and hyperinsulinemia with some mice exhibiting hyperglycemia. Symptoms occur much later, between 5 and 8 months of age, than most of the single gene obese and diabetic strains. In addition, male mice are susceptible to the diabetogenic effects of multiple low doses of streptozotocin (40 mg/kg BW.day X 5).
This strain was created, beginning in 1948, by George Snell by transferring the H2b haplotype from a mouse of an outbred Swiss stock onto the C3H/HeDiSn inbred strain by 11 rounds of backcross-intercross breeding (Snell 1958).
|Allele Name||b variant|
|Allele Type||Not Applicable|
|Gene Symbol and Name||H2, histocompatibility-2, MHC|
|Strain of Origin||Not Applicable|
|General Note||The b variant has been observed in the following strains: C57BL/10, C57BL/10SnJ, BXSB/MpJ, C57BL/6J, C57L/J, LP/J, 129P3/J, 129P1/ReJ.|
|Allele Name||a variant|
|Allele Type||Spontaneous (Not Applicable)|
|Gene Symbol and Name||B2m, beta-2 microglobulin|
|Strain of Origin||multiple strains|
|Molecular Note||The a variant is slightly slower running on SDS PAGE and was found to have an aspartic acid at amino acid position 85. This allele is found in A, BALB/c, LP and most other strains.|
When using the C3.SW-H2b/SnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000438 in your Materials and Methods section.