B10.D2-H8^b/(57N)SnJ

Stock number: 000426
Product name: B10.D2(57N)/Sn
Research areas: Immunology, Inflammation and Autoimmunity Research

Detailed description

This B10 congenic strain carries the H8^b allele from D2.WA/Sn (H2^b).

Development

This is one of the “Congenic Resistant” strains of mice developed by George D. Snell in his studies of histocompatibility. [Snell, G.D. 1978. In Origins of Inbred Mice (H.C. Morse III, ed.). Academic Press, New York. The strain was erroneously listed as B10. C (57N)/Sn in Table 3.]

The H8^b allele from another congenic strain made by Snell, D2.WA/Sn (WA was a non-inbred strain with the genotype H2^b/H2^b, A/a, Tyrp^b/Typr⁺, Myo15^sh2/Myo15^sh2) was transferred onto C57BL/10ScSn by the equivalent of 8 generations of backcrossing before being maintained by sib matings. The strain was cryopreserved in 1994 at generation NE8F108.

Allele

MGI accession ID: MGI:96007
Marker symbol: H8
Marker name: histocompatibility 8
Chromosome: 14