B6.PL-Cd8a^a Cd8b1^a/(75NS)CyJ

Stock number: 000407
Product name: B6.PL(75NS)/Cy
Research areas: Immunology, Inflammation and Autoimmunity Research

Detailed description

This congenic strain carries the T-cell Cd8a^a and Cd8b1^a co-receptor alleles from the PL/J strain on a C57BL/6J genetic background.

Development

Cd8a^a and Cd8b1^a are closely linked on chromosome 6 and were backcrossed from PL/J onto C57BL/6J. At the 10th backcross generation, this subline, designated 75NS, was extracted by sibling mating between N11 mice. Continuing backcrosses to N30 produced the 85NS line - B6.PL-Cd8a^a Cd8b1^a/(85NS)CyJ (001065). (Gibson et al., 1983.)

Allele

MGI accession ID: MGI:88346
Marker symbol: Cd8a
Marker name: CD8 antigen, alpha chain
Marker synonyms: CD8; CD8alpha; IMD116; Leu2; Ly-2; Ly-35; Ly-B; Lyt-2; p32
Chromosome: 6

Allele

MGI accession ID: MGI:88347
Marker symbol: Cd8b1
Marker name: CD8 antigen, beta chain 1
Marker synonyms: CD8B1; CD8beta; CD8BP; LEU2; LY3; Ly-3; Ly-C; LYT3; Lyt-3; P37
Chromosome: 6