B6.C-Ifi44l^H28-c If1^l/(HW94)bByJ

Stock number: 000384
Product name: HW94
Research areas: Immunology, Inflammation and Autoimmunity Research

Detailed description

This B6/By congenic strain, originally developed on the basis of a histoincompatibility with the BALB/cBy strain, initially named H-28^c, and currently named Ifi44l^c. The strain also carries the If1^l allele from BALB/cBy. See also Stock No. 000116, Stock No. 000142, and Stock No. 000146. These independently derived congenic strains all carry a BALB/cBy Chromosome 3 segment containing Ifi44l^c.

Development

Dr. Donald Bailey, then at University of California Medical Center in San Francisco, began to generate a panel of congenic lines with differential loci that determine histocompatibility by crossing BALB/cBy females with C57BL/6By males, and then backcrossing at each generation to a C57BL/6J male. At backcross generation 5 orthotopic tailskin graft tests were done to identify lines bearing BALB/cBy-derived congenic intervals with histocompatibility loci. This backcrossing, with testing, was continued until siblings at backcross generation 11 or more were intercrossed to breed the congenic interval to homozygosity and each strain was maintained by sibling inbreeding (Bailey 1975 Immunogenetics 2:249-56). Dr. Bailey transferred the mice to The Jackson Laboratory when he joined the staff in 1967. The strain was cryopreserved in 1981 at generation N15F44.

Allele

Symbol: Ifi44l^H28-c
Name: histocompatibility 28, c variant
MGI accession ID: MGI:6199480
Generation method: Spontaneous
Attributes: Not Applicable
Marker symbol: Ifi44l
Marker name: interferon-induced protein 44 like
Chromosome: 3
Strain of origin: BALB/cBy
Molecular note: This minor histocompatibility antigen, formerly designated H28, was traced to the ILENFPRL peptide from this gene in the BALB/cBy genome, distinct from the sequence in the C57BL/6J genome. This peptide is presented in K^b and stimulates C57BL/6By hosts to reject BALB.B grafts.

Allele

Symbol: If1^l
Name: low response
MGI accession ID: MGI:6201402
Generation method: Spontaneous
Attributes: Hypomorph
Marker symbol: If1
Marker name: NDV-induced circulating interferon
Chromosome: 3
Strain of origin: BALB/c
Molecular note: This phenotypic variation causing decreased interferon production in response to particular stimuli has been mapped to distal Chromosome 3