B6.C-H15^c/(HW13J)ByJ

Stock number: 000382
Product name: HW13J
Research areas: Immunology, Inflammation and Autoimmunity Research

Detailed description

This B6/By congenic strain carries the ‘minor’ histocompatibility allele, H15^c, from BALB/cBy.

Development

Dr. Donald Bailey, then at University of California Medical Center in San Francisco, began to generate a panel of congenic lines with differential loci that determine histocompatibility by crossing BALB/cBy females with C57BL/6By males, and then backcrossing at each generation to a C57BL/6J male. At backcross generation 5 orthotopic tailskin graft tests were done to identify lines bearing BALB/cBy-derived congenic intervals with histocompatibility loci. This backcrossing, with testing, was continued until siblings at backcross generation 11 or more were intercrossed to breed the congenic interval to homozygosity and each strain was maintained by sibling inbreeding (Bailey, 1975). Dr. Bailey transferred the mice to The Jackson Laboratory when he joined the staff in 1967.

This congenic strain carries portion of Chromosome 4 from BALB/cBy and has a shorter congenic interval than its parent, B6.C/(HW13)ByJ (Stock No. 000115), being approximately 15 cM and including H15, Mup1, and interferon alpha cluster, but not Tyrp1^b, H16, H20, or H21. The strain was cryopreserved in 1981.

Allele

MGI accession ID: MGI:95887
Marker symbol: H15
Marker name: histocompatibility 15
Chromosome: 4