B6.C-H2^d Mdmg1^BALB/cBy/aByJ

Stock number: 000360
Product name: HW19
Research areas: Immunology, Inflammation and Autoimmunity Research

Detailed description

This B6/By strain carries the H2^b histocompatibility allele from BALB/cBy along with an allele affecting mandible shape (Mdmg1^BALB/cBy) that confers elgonation of the dorsal edge of thecondylar process. The Mdmg1 locus has been located proximal to the H2 locus.

Development

Dr. Donald Bailey, then at University of California Medical Center in San Francisco, began to generate a panel of congenic lines with differential loci that determine histocompatibility by crossing BALB/cBy females with C57BL/6By males, and then backcrossing at each generation to a C57BL/6J male. At backcross generation 5 orthotopic tailskin graft tests were done to identify lines bearing BALB/cBy-derived congenic intervals with histocompatibility loci. This backcrossing, with testing, was continued until siblings at backcross generation 11 or more were intercrossed to breed the congenic interval to homozygosity and each strain was maintained by sibling inbreeding (Bailey, 1975). Dr. Bailey transferred the mice to The Jackson Laboratory when he joined the staff in 1967. The strain was cryopreserved in 1981 at generation N15F44.

Allele

Symbol: Mdmg1^BALB/cBy
Name: BALB/cBy
MGI accession ID: MGI:3615645
Generation method: QTL
Marker symbol: Mdmg1
Marker name: mandibular morphogenesis 1
Chromosome: 17
Strain of origin: BALB/cBy
Molecular note: This allele confers elongation of the mandible compared to C57BL/6J.

Allele

Symbol: H2^d
Name: d variant
MGI accession ID: MGI:3579320
Generation method: Spontaneous
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Chromosome: 17
Strain of origin: various
General note: The d variant has been observed in the following strains: DBA/2, DBA/2J BALB/c, BALB/cByJ, BALB/cJ, C57BLKS, NZB.