Npr2cn is a spontaneous mutation that was found in 1960 in the AKR/J colony at The Jackson Laboratory. This mutation was backcrossed three generations to C57BL/6J, then backcrossed four generations to C3H/HeDiSn, then crossed once to AKR/J, then backcrossed two generations to LG/J, then sibling mated heterozygote x heterozygote until F50 before freezing by sibling mating.
|Allele Type||Spontaneous (Null/Knockout)|
|Gene Symbol and Name||Npr2, natriuretic peptide receptor 2|
|Strain of Origin||AKR/J|
|Molecular Note||The molecular basis of this mutation is a T-to-G transversion resulting in a leucine to arginine change in codon 885 (p.L885R). This is a missence mutation resulting in production of an inactive form of Npr2.|
When using the STOCK Npr2cn/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000294 in your Materials and Methods section.