Overview

Genetic overview

Genetic Background	Generation

fd

Allele Type	Gene Symbol	Gene Name
Spontaneous	fd	fur deficient

a

Allele Type	Gene Symbol	Gene Name
Spontaneous	a	nonagouti

Allele Type	Gene Symbol	Gene Name
Spontaneous	Myo5a	myosin VA

Research Applications

Dermatology Research
Mouse/Human Gene Homologs

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Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

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Details

Development

Fur deficient (fd) arose spontaneously in DBA/2J in 1966 at The Jackson Laboratory. It was outcrossed to C57BL/6J once and the F1 was backcrossed to a DBA2/J-fd homozygote. It was then sibling mated using a Myo5a^d fd/Myo5a^d fd male and a Myo5a^d fd/+ + female. Close linkage was found between Myo5a^d and fd and the stock was maintained by sibling matings keeping the two loci in coupling phase. It was cryopreserved in 1991 by mating Myo5a^d fd/Myo5a^d fd or Myo5a^d fd/+ + males at F47 to C57BL/6J females.

Control Suggestions

Heterozygote from the colony

Additional Information

Considerations for Choosing Controls

Genetics

fd

Allele Symbol: fd

Allele Name	fur deficient
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	fd, fur deficient
Gene Synonym(s)
Strain of Origin	DBA/2J
Chromosome	9

a

Allele Symbol: a

Allele Name	nonagouti
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	a, nonagouti
Gene Synonym(s)
Strain of Origin	old mutant of the mouse fancy
Chromosome	2
General Note	Insertion of the LV30 retrotransposon without the beta4 retrovirus sequence does not cause the nonagouti phenotype. J:278039
Molecular Note	Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats (beta4 retroviral sequence). The host integration site is the same as for a^t-2Gso and A^w-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type.

Myo5a^d

Allele Symbol: Myo5a^d

Allele Name	dilute
Allele Type	Spontaneous
Allele Synonym(s)	blue dilution; d; d^v; Maltese dilution
Gene Symbol and Name	Myo5a, myosin VA
Gene Synonym(s)
Strain of Origin	old mutant of the mouse fancy
Chromosome	9
Molecular Note	This mutation is the result of the integration of ecotropic murine leukemia virus Emv-3 into a noncoding region of the Myo5a^d gene. Reversions of Myo5a^d to wild-type are caused by excision of the virus leaving exactly one long terminal repeat in place.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: fd related

Dermatology Research
- Skin and Hair Texture Defects

Genotype: Myo5a^d related

Dermatology Research
- Color and White Spotting Defects
Mouse/Human Gene Homologs
- Griscelli Syndrome

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: fd/fd
DBA/2J-fd

integument phenotype

abnormal coat appearance
- recognized before weaning

abnormal coat/ hair morphology

abnormal zigzag hair morphology
- less underfur than expected

decreased zigzag hair amount
- gives the illusion that hair coat is longer

sparse hair
- all hair types are present but underrepresented

References

Additional - a related

Additional - fd related

Additional - Myo5a^d related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Breeding Considerations

Myo5^d and fd are linked on chromosome 9 and maintained in coupling in this strain.

When maintaining a live colony, mice can be bred as heterozygote x homozygote or homozygote x heterozygote for Myo5a^d; and heterozygote x homozygote or homozygote x heterozygote for fd.
- Additional Breeding and Husbandry Support
Appearance
- nonagouti (black)
  Related Genotype: a/a Myo5a^d fd/++
  
  dilute
  Related Genotype: a/a Myo5a^dfd /Myo5a^dfd
Citation
When using the STOCK a/a Myo5a^d fd/+ +/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000286 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Homozygous for a, Heterozygous for Myo5a<d>, Heterozygous for fd

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

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