Genetic Background | Generation |
---|---|
003588 LT/SvEi |
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | a | nonagouti |
LT/SvEi is homozygous for the nonagouti (a) mutation. The Agouti allele (A) was backcrossed from CAST/Ei onto LT/SvEi for 10 generations before intercrossing. In 1987 N10F28 homozygotes were bred together to generate embryos for cryopreservation. (Eppig and Eicher, 1983.)
Allele Name | wild-type agouti |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | dark-bellied agouti |
Gene Symbol and Name | a, nonagouti |
Gene Synonym(s) | |
Strain of Origin | various |
Chromosome | 2 |
General Note | The A allele is usually regarded as a wild-type allele. For example,the C3H and CBA mouse sublines are homozygous for agouti. Hairs are black with a subapical yellow band. This black-yellow-black pattern is referred to as agouti. The general appearance is yellowish brown, slightly lighter on the belly than on the back. |
Molecular Note | This allele, often referred to as wild-type, comprises a novel 131 amino acid protein encoded in a gene comprising four exons, three coding, spanning 18kb. Unique changes in this gene account for all other alleles that have been molecularly characterized. The expression of this allele is almost always dominant to other alleles of this gene. |
When using the LT.CAST-A/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000283 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Inbred, 1 pair minimum will be supplied |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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