C3H/HeJ-Mgrn1^md/J

Stock number: 000223
Research areas: Dermatology Research

Development

Mahoganoid (Mgrn^md) arose spontaneously in strain C3H/HeJ at the Jackson Laboratory in 1957. Homozygotes were sibling mated to F5 and then a homozygous female was crossed to an unpedigreed C3H/HeJ male. The stock was then sibling mated using forced heterozygosis. It was cryopreserved in 1998 at F158 by mating homozygous females to heterozygous males.

Allele

Symbol: Mgrn1^md
Name: mahoganoid
MGI accession ID: MGI:1856070
Generation method: Spontaneous
Marker symbol: Mgrn1
Marker name: mahogunin, ring finger 1
Chromosome: 16
Strain of origin: C3H/HeJ
Molecular note: The mutation in md has been attributed to a 5 kb retroviral insertion located in the intronic region 5' of exon 12. Northern analysis and RT-PCR indicate that the expression of transcript is greatly reduced in these mice.
General note: The original md mutation arose in the C3H/HeJ strain. This gene is similar to mahogany (Atrn^mg) in its effects on coat color, but causes less darkening of the back, ears, and tail of agouti mice (J:13379)(J:13791).