Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Mgrn1 | mahogunin, ring finger 1 |
Mahoganoid (Mgrnmd) arose spontaneously in strain C3H/HeJ at the Jackson Laboratory in 1957. Homozygotes were sibling mated to F5 and then a homozygous female was crossed to an unpedigreed C3H/HeJ male. The stock was then sibling mated using forced heterozygosis. It was cryopreserved in 1998 at F158 by mating homozygous females to heterozygous males.
Allele Name | mahoganoid |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | md |
Gene Symbol and Name | Mgrn1, mahogunin, ring finger 1 |
Gene Synonym(s) | |
Strain of Origin | C3H/HeJ |
Chromosome | 16 |
General Note | The original md mutation arose in the C3H/HeJ strain. This gene is similar to mahogany (Atrnmg) in its effects on coat color, but causes less darkening of the back, ears, and tail of agouti mice (J:13379)(J:13791). |
Molecular Note | The mutation in md has been attributed to a 5 kb retroviral insertion located in the intronic region 5' of exon 12. Northern analysis and RT-PCR indicate that the expression of transcript is greatly reduced in these mice. |
When using the C3H/HeJ-Mgrn1md/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000223 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Homozygous for Mgrn1<md>, 1 pair minimum |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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