These mice carry a spontaneous remutation at the Kit locus characterized by homozygous lethality and white spotting and polycythemia in heterozygotes.Read More +
Mutations at the Kit locus affect various aspects of hematopoiesis, the proliferation and migration of primordial germ cells and melanoblasts during development. The original KitW mutation and KitW-35J are lethal mutations when homozygous. KitW-35J heterozygotes exhibit borderline polycythemia, and phenotypic effects are almost indistinguishable from those of the classic KitW allele.
Embryos were cryopreserved in 1980 by mating heterozygous males to C57BL/6J females.