Allele Name	patch
Allele Type	Spontaneous
Allele Synonym(s)	Pdgfr^Ph
Gene Symbol and Name	Ph, patch deletion region
Gene Synonym(s)
Strain of Origin	C57BL/Gr
Chromosome	5
General Note	Repulsion double heterozygotes of Ph and the allele Kit^W-ct at the closely linked Kit locus (Ph +/+ Kit^W-ct) are more anemic than Kit heterozygotes (+ Kit^W-ct/+ +) alone, have significantly raised leucocyte counts, and are unduly sensitive to whole body X-irradiation, indicating that the Ph locus exerts some control over hematopoiesis (J:7216). Studies of Ph homozygous embryos suggest that Ph protein is required for normal development of non-neuronal neural crest-derived structures (J:1107) and visceral endoderm and mesoderm derivatives (J:1108).
Molecular Note	A deletion region including the Pdgfra gene. Precise breakpoints have not been mapped, but does not extend into the coding sequences of the adjacent Kit gene. However, expression of Kit is altered in these mutants.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Ph related

Cancer Research
- Growth Factors/Receptors/Cytokines
Dermatology Research
- Color and White Spotting Defects
Developmental Biology Research
- Craniofacial and Palate Defects
- Embryonic Lethality (Homozygous)
- Neural Crest Defects
Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Ph/Ph⁺
involves: C57BL/Gr

integument phenotype

belly spot

variable body spotting
- heterozygotes have a large white patch of variable shape and size at the posterior extremity of the trunk, largely on the ventral side

pigmentation phenotype

belly spot

variable body spotting
- heterozygotes have a large white patch of variable shape and size at the posterior extremity of the trunk, largely on the ventral side

References

Additional References

Duttlinger R; Manova K; Berrozpe G; Chu TY; DeLeon V; Timokhina I; Chaganti RS; Zelenetz AD; Bachvarova RF; Besmer P. 1995. The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice. Proc Natl Acad Sci U S A 92(9):3754-8PubMed: 7537375 MGI: J:25082
Morrison-Graham K; Schatteman GC; Bork T; Bowen-Pope DF; Weston JA. 1992. A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells. Development 115(1):133-42PubMed: 1638976 MGI: J:1107
Orr-Urtreger A; Bedford MT; Do MS; Eisenbach L; Lonai P. 1992. Developmental expression of the alpha receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation. Development 115(1):289-303PubMed: 1322271 MGI: J:1104
Schatteman GC; Morrison-Graham K; van Koppen A; Weston JA; Bowen-Pope DF. 1992. Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis. Development 115(1):123-31PubMed: 1322269 MGI: J:1108
Stephenson DA; Mercola M; Anderson E; Wang CY; Stiles CD; Bowen-Pope DF; Chapman VM. 1991. Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation. Proc Natl Acad Sci U S A 88(1):6-10PubMed: 1846043 MGI: J:10920

Additional - Ph related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Citation
When using the C57BL/6J-Ph/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000118 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Heterozygous or Wild-type for Ph

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

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Genetic overview

Research Applications

Base Price

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Additional Information

Ph

Allele Symbol: Ph