C57BL/6J-Ph/J

Stock number: 000118
Research areas: Cancer Research, Dermatology Research, Developmental Biology Research, Immunology, Inflammation and Autoimmunity Research

Allele

Symbol: Ph
Name: patch
MGI accession ID: MGI:1857106
Generation method: Spontaneous
Marker symbol: Ph
Marker name: patch deletion region
Chromosome: 5
Strain of origin: C57BL/Gr
Molecular note: A deletion region including the Pdgfra gene. Precise breakpoints have not been mapped, but does not extend into the coding sequences of the adjacent Kit gene. However, expression of Kit is altered in these mutants.
General note: Repulsion double heterozygotes of Ph and the allele Kit^W-ct at the closely linked Kit locus (Ph +/+ Kit^W-ct) are more anemic than Kit heterozygotes (+ Kit^W-ct/+ +) alone, have significantly raised leucocyte counts, and are unduly sensitive to whole body X-irradiation, indicating that the Ph locus exerts some control over hematopoiesis (J:7216). Studies of Ph homozygous embryos suggest that Ph protein is required for normal development of non-neuronal neural crest-derived structures (J:1107) and visceral endoderm and mesoderm derivatives (J:1108).