This B6/By congenic strain carries a portion of Chromosome 4 from BALB/cBy including the ‘minor’ histocompatibility alleles, H15c, H16c, H20c, and H21c along with Tyrp1b, Mup1 and the interferon alpha cluster. Dubey et al. (1993) reported heightened NK cell activity in this Chromosome 4 congenic. Bailey (1985) reported a change, compared with the C57BL/6By host, in mandible shape, longbone length, and curvature and thickness of lower incisors.
Don Bailey, The Jackson Laboratory
Genetic Background | Generation |
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000663 C57BL/6By |
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Marker Symbol | Marker Name | |
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H20 | histocompatibility 20 | |
H15 | histocompatibility 15 | |
H16 | histocompatibility 16 | |
H21 | histocompatibility 21 |
This B6/By congenic strain carries a portion of Chromosome 4 from BALB/cBy including the ‘minor’ histocompatibility alleles, H15c, H16c, H20c, and H21c along with Tyrp1b, Mup1 and the interferon alpha cluster. Dubey et al. (1993) reported heightened NK cell activity in this Chromosome 4 congenic. Bailey (1985) reported a change, compared with the C57BL/6By host, in mandible shape, longbone length, and curvature and thickness of lower incisors.
Dr. Donald Bailey, then at University of California Medical Center in San Francisco, began to generate a panel of congenic lines with differential loci that determine histocompatibility by crossing BALB/cBy females with C57BL/6By males, and then backcrossing at each generation to a C57BL/6J male. At backcross generation 5 orthotopic tailskin graft tests were done to identify lines bearing BALB/cBy-derived congenic intervals with histocompatibility loci. This backcrossing, with testing, was normally continued until siblings at backcross generation 11 or more were intercrossed to breed the congenic interval to homozygosity and each strain was maintained by sibling inbreeding (Bailey, 1975). This strain was backcrossed for 9 generations before sibling intercross matings. Dr. Bailey transferred the mice to The Jackson Laboratory when he joined the staff in 1967. The strain was cryopreserved in 1980 at generation F9
When using the B6.C/(HW13)ByJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000115 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Inbred, 1 pair minimum will be supplied |
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