B6.C/(HW13)ByJ

Stock number: 000115
Research areas: Immunology, Inflammation and Autoimmunity Research

Detailed description

This B6/By congenic strain carries a portion of Chromosome 4 from BALB/cBy including the ‘minor’ histocompatibility alleles, H15^c, H16^c, H20^c, and H21^c along with Tyrp1^b, Mup1 and the interferon alpha cluster. Dubey et al. (1993) reported heightened NK cell activity in this Chromosome 4 congenic. Bailey (1985) reported a change, compared with the C57BL/6By host, in mandible shape, longbone length, and curvature and thickness of lower incisors.

Development

Dr. Donald Bailey, then at University of California Medical Center in San Francisco, began to generate a panel of congenic lines with differential loci that determine histocompatibility by crossing BALB/cBy females with C57BL/6By males, and then backcrossing at each generation to a C57BL/6J male. At backcross generation 5 orthotopic tailskin graft tests were done to identify lines bearing BALB/cBy-derived congenic intervals with histocompatibility loci. This backcrossing, with testing, was normally continued until siblings at backcross generation 11 or more were intercrossed to breed the congenic interval to homozygosity and each strain was maintained by sibling inbreeding (Bailey, 1975). This strain was backcrossed for 9 generations before sibling intercross matings.  Dr. Bailey transferred the mice to The Jackson Laboratory when he joined the staff in 1967. The strain was cryopreserved in 1980 at generation F9

Allele

MGI accession ID: MGI:95888
Marker symbol: H16
Marker name: histocompatibility 16
Chromosome: 4

Allele

MGI accession ID: MGI:95967
Marker symbol: H20
Marker name: histocompatibility 20
Chromosome: 4

Allele

MGI accession ID: MGI:95968
Marker symbol: H21
Marker name: histocompatibility 21
Chromosome: 4

Allele

MGI accession ID: MGI:95887
Marker symbol: H15
Marker name: histocompatibility 15
Chromosome: 4