This inbred mutant strain carries the jagged tail (jg) and buff (Vps33abf) mutations. The microwave induced increase in complement receptor B cells; responder allele (MicrlR) is also found in this strain.Read More +
Mice homozygous for the recessive buff (Vps33abf) mutation on a non-agouti (a/a) background have a lightened coat color that has been described as khaki. On an agouti background, Vps33abf homozygotes have dark ears, opaque eyes, and the belly is lighter in color than is the rest of the coat. Although no change in eye color is outwardly evident, electron microscopy shows fewer and smaller melanosomes than normal in the retinal pigment epithelium and choroid. These mutants have a platelet-storage pool defect evidenced by an increased bleeding time of 9.7 minutes on average, a reduction in the number of platelet dense granules, and slightly decreased collagen-mediated platelet aggregation, secretion of dense-granule ATP and secretion of seratonin. Hakansson and Lundin found increased activity of the lysosomal glycosidases beta- galactosidase, beta-glucuronidase, and N-acetyl-beta-hexosaminidase in kidney cell lysates. Suzuki et al. found no significant difference in kidney beta- galactosidase and beta-glucuronidase activity, no significant decrease in beta-glucuronidase secretion into the urine, but a 53% reduction in the secretion of beta-galactosidase into the urine. (Dickie, 1964; Davisson, 1977; Hakansson and Lundin, 1977; Suzuki et al., 2003.)
Mice homozygous for jg have shortened tails with a normal tapering tip. There is variation in expressivity. The tail is often kinked and other parts of the spine can also be affected. Testes are much smaller than normal and homozygous males are likely sterile. Ovaries are slightly smaller than normal and litter sizes from homozygous females are smaller than normal. Viability to wean age is reduced in homozygotes impacting males more than females. (Green, 1964.)
|Gene Symbol and Name||Vps33a, VPS33A CORVET/HOPS core subunit|
|Strain of Origin||C57BL/6J|
|Molecular Note||This allele comprises a T-to-G transversion that causes a missense substitution of aspartic acid to glutamic acid at codon 251 (p.D251E).|
|Gene Symbol and Name||Micrl, microwave induced increase in complement receptor B cells|
|Strain of Origin||multiple strains|
|General Note||Carriers of this dominant QTL respond to microwave exposure with an increase in splenic C3 receptor-bearing B cells. The following inbred strains are homozygous for Micrl |
Homozygous jg/jg usually dies at birth.
When using the JGBF/LeTyJ mouse strain in a publication, please include JAX stock #000072 in your Materials and Methods section.