Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Mc1r | melanocortin 1 receptor |
The recessive yellow mutation (Mc1re) arose in 1963 in a C57BL/6Ha strain homozygous for Kitw at Roswell Park Memorial Institute. By 1970 Dr. Elizabeth Russell had imported Mc1re on the C57BL/6Ha background into The Jackson Laboratory and began backcrossing it onto C57BL/6J. In 1974 the strain, maintained by backcross-intercross, had reached generation N8, in 1976 it reached generation N12, in 1978 it reached generation N18, and in 1979 it was cryopreserved at generation N20.
Allele Name | recessive yellow |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | e; MC1-; Mc1r- |
Gene Symbol and Name | Mc1r, melanocortin 1 receptor |
Gene Synonym(s) | |
Strain of Origin | C57BL/6Ha |
Chromosome | 8 |
Molecular Note | The mutation is a frameshift due to a deletion of a single nucleotide at position 549. This mutation is predicted to result in a protein that continues out of frame for 12 amino acids before terminating. |
When using the C57BL/6J-Mc1re/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000060 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Mc1r<e> |
Frozen Mouse Embryo | C57BL/6J-Mc1r<e>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Mc1r<e>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Mc1r<e>/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | C57BL/6J-Mc1r<e>/J Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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