Overview

Genetic overview

Genetic Background	Generation

Mc1r^e

Allele Type	Gene Symbol	Gene Name
Spontaneous	Mc1r	melanocortin 1 receptor

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Research Applications

Dermatology Research
Endocrine Deficiency Research

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Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

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Details

Development

The recessive yellow mutation (Mc1r^e) arose in 1963 in a C57BL/6Ha strain homozygous for Kit^w at Roswell Park Memorial Institute. By 1970 Dr. Elizabeth Russell had imported Mc1r^e on the C57BL/6Ha background into The Jackson Laboratory and began backcrossing it onto C57BL/6J. In 1974 the strain, maintained by backcross-intercross, had reached generation N8, in 1976 it reached generation N12, in 1978 it reached generation N18, and in 1979 it was cryopreserved at generation N20.

Genetics

Mc1r^e

Allele Symbol: Mc1r^e

Allele Name	recessive yellow
Allele Type	Spontaneous
Allele Synonym(s)	Mc1r^e; recessive yellow
Gene Symbol and Name	Mc1r, melanocortin 1 receptor
Gene Synonym(s)	Mshra; SHEP2; extension recessive yellow; CMM5; tobacco darkening; e; Tob; MSH-R; e; melanocyte hormone receptor alpha; Mshra; extension, recessive yellow; Mcr1
Strain of Origin	C57BL/6Ha
Chromosome	8
Molecular Note	The mutation is a frameshift due to a deletion of a single nucleotide at position 549. This mutation is predicted to result in a protein that continues out of frame for 12 amino acids before terminating.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Mc1r^e related

Dermatology Research
- Skin and Hair Texture Defects
- Color and White Spotting Defects
  - red hair color
Endocrine Deficiency Research
- Skin Defects

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Mc1r^e/Mc1r^e
involves: C57BL/6Ha

integument phenotype

abnormal hair follicle melanogenesis
- neural tube-skin recombination grafting technique demonstrates that phaeomelanin (yellow coat color) is controlled by melanocyte genotype; not skin genotype

abnormal hair follicle pheomelanosome pheomelanin content
- the phaeomelanin to total melanin ratio is much higher (2.73) than in agouti controls (0.19)

yellow coat color
- mice have a yellow coat
- the clear yellow color accentuates the normal black eye color
- the entire length of the hair is yellow in adults; prior to weaning, homozygotes exhibit some dorsally concentrated umbrous sootiness but acquire an overall yellow coat with sucessive molts
- young mice have some eumelanin deposited in the hair tips, but adults have hairs predominantly pigmented with pheomelanin

pigmentation phenotype

abnormal hair follicle melanogenesis
- neural tube-skin recombination grafting technique demonstrates that phaeomelanin (yellow coat color) is controlled by melanocyte genotype; not skin genotype

abnormal hair follicle pheomelanosome pheomelanin content
- the phaeomelanin to total melanin ratio is much higher (2.73) than in agouti controls (0.19)

yellow coat color
- mice have a yellow coat
- the clear yellow color accentuates the normal black eye color
- the entire length of the hair is yellow in adults; prior to weaning, homozygotes exhibit some dorsally concentrated umbrous sootiness but acquire an overall yellow coat with sucessive molts
- young mice have some eumelanin deposited in the hair tips, but adults have hairs predominantly pigmented with pheomelanin

The following phenotype relates to a compound genotype created using this strain

Genotype: Mc1r^e/Mc1r^e
C57BL/6J-Mc1r/J

cellular phenotype

abnormal keratinocyte apoptosis
- forskolin pre-treatment produces UV protection similar to wild-type (black skinned) mice while untreated mutants are very UV-sensitive; untreated mice show formation of sunburn cells 24 hours after UV exposure

increased cellular sensitivity to ionizing radiation

integument phenotype

abnormal keratinocyte apoptosis
- forskolin pre-treatment produces UV protection similar to wild-type (black skinned) mice while untreated mutants are very UV-sensitive; untreated mice show formation of sunburn cells 24 hours after UV exposure

abnormal skin pigmentation
- mice show no UV-induced detectable pigmentation changes, while wild-type ears show grossly and microscopically detectable hyperpigmentation

pigmentation phenotype

abnormal melanogenesis
- in mutants, no measurable UV-induced melanization is observed; forskolin application to the skin induces significant skin darkening

abnormal skin pigmentation
- mice show no UV-induced detectable pigmentation changes, while wild-type ears show grossly and microscopically detectable hyperpigmentation

Genotype: Mc1r^e/Mc1r^e
involves: C57BL/6

behavior/neurological phenotype

abnormal pain threshold
- males display significantly higher latencies than females for the 49 degree water tail withdrawal test

abnormal touch/ nociception
- mutant females and males display reduced pain sensitivity

analgesia
- 6-10 week old females and males display increased analgesic responsiveness to morphine-6-glucuronide when challenged with thermal nociception

integument phenotype

abnormal pain threshold
- males display significantly higher latencies than females for the 49 degree water tail withdrawal test

abnormal touch/ nociception
- mutant females and males display reduced pain sensitivity

analgesia
- 6-10 week old females and males display increased analgesic responsiveness to morphine-6-glucuronide when challenged with thermal nociception

References

Additional References

Robbins LS; Nadeau JH; Johnson KR; Kelly MA; Roselli-Rehfuss L; Baack E; Mountjoy KG; Cone RD. 1993. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72(6):827-34PubMed: 8458079 MGI: J:4636

Additional - Mc1r^e related

Technical Support

Contact Technical Support

Genotyping Protocols
- End Point Analysis: Mc1r^e
- Genotyping resources and troubleshooting
Citation
When using the C57BL/6J-Mc1r^e/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000060 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service	Genotype	Price
	Heterozygous for Mc1r<e>

We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

Related Products and Services

Frozen Mouse Embryo

$2,595.00 per straw or vial

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Licensing Information

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JAX® Mice, Products & Services Conditions of Use

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Genetic overview

Research Applications

Base Price

Development

Mc1re

Allele Symbol: Mc1re

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Mc1re related

Mammalian Phenotype Terms by Genotype

Genotype: Mc1re/Mc1reinvolves: C57BL/6Ha

integument phenotype

pigmentation phenotype

Genotype: Mc1re/Mc1reC57BL/6J-Mc1r/J

cellular phenotype

integument phenotype

pigmentation phenotype

Genotype: Mc1re/Mc1reinvolves: C57BL/6

behavior/neurological phenotype

integument phenotype

References

Additional References

Additional - Mc1re related

Genotyping Protocols

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Related Products and Services

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Mc1r^e

Allele Symbol: Mc1r^e

Genotype: Mc1r^e related

Genotype: Mc1r^e/Mc1r^e
involves: C57BL/6Ha

Genotype: Mc1r^e/Mc1r^e
C57BL/6J-Mc1r/J

Genotype: Mc1r^e/Mc1r^e
involves: C57BL/6

Additional - Mc1r^e related