The recessive yellow mutation (Mc1re) arose in 1963 in a C57BL/6Ha strain homozygous for Kitw at Roswell Park Memorial Institute. By 1970 Dr. Elizabeth Russell had imported Mc1re on the C57BL/6Ha background into The Jackson Laboratory and began backcrossing it onto C57BL/6J. In 1974 the strain, maintained by backcross-intercross, had reached generation N8, in 1976 it reached generation N12, in 1978 it reached generation N18, and in 1979 it was cryopreserved at generation N20.
|Allele Name||recessive yellow|
|Allele Synonym(s)||e; MC1-; Mc1r-|
|Gene Symbol and Name||Mc1r, melanocortin 1 receptor|
|Strain of Origin||C57BL/6Ha|
|Molecular Note||The mutation is a frameshift due to a deletion of a single nucleotide at position 549. This mutation is predicted to result in a protein that continues out of frame for 12 amino acids before terminating.|