B6.D2-Tyr^c-p/J

Stock number: 000054
Research areas: Dermatology Research, Mouse/Human Gene Homologs

Detailed description

The coat color of mice homozygous for the platinum mutation is nearly albino, cream colored, and these mice have pink eyes and a sheen to their coat. These homozygotes are lighter in color than chinchilla homozygotes despite having more tyrosinase activity in their cells. This is due to the altered subcellular localization of platinum tyrosinase. (Dickie M., 1966.)

Allele

Symbol: Tyr^c-p
Name: platinum
MGI accession ID: MGI:1855981
Generation method: Spontaneous
Synonyms: c^P
Marker symbol: Tyr
Marker name: tyrosinase
Marker synonyms: ATN; CMM8; Oca1; OCA1A; OCAIA; SHEP3; skc35
Chromosome: 7
Strain of origin: DBA/2J
Molecular note: The mutation in the platinum allele was found to be an A-to-T substitution, changing a lysine residue at position 507 or 489 to a termination codon (p.K507* for pre-protein, p.K489* for mature protein).