Mice heterozygous for the extra toes-J spontaneous mutation (Gli3Xt-J) have varying numbers of extra digits on preaxial side of feet. Homozygous mutant mice die in utero with multiple abnormalities. Excessively large pharyngeal arches and an open neural tube are evident at E9. Homologous to Grieg's cephalopoly-syndactyly, a rare multi-system syndrome in humans.
Genetic Background | Generation |
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000664 C57BL/6J |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Gli3 | GLI-Kruppel family member GLI3 |
Mice heterozygous for the extra toes-J spontaneous mutation (Gli3Xt-J) have varying numbers of extra digits on preaxial side of feet. Homozygous mutant mice die in utero with multiple abnormalities. Excessively large pharyngeal arches and an open neural tube are evident at E9. Homologous to Grieg's cephalopoly-syndactyly, a rare multi-system syndrome in humans.
Allele Name | extra toes Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | extra-toes J; Gli3-; Gli3delta; Gli3Xt; Gli3XtJ; xt; XtJ; XtJ |
Gene Symbol and Name | Gli3, GLI-Kruppel family member GLI3 |
Gene Synonym(s) | |
Strain of Origin | C3H/HeJ |
Chromosome | 13 |
General Note | Genbank ID for this allele: AF418601 Phenotypic Similarity to Human Syndrome: lambdoid suture craniosynostosis in homozygous mice (J:163175) |
Molecular Note | Genomic sequencing and PCR analysis identified the mutation as a 51.5 kb deletion. The deleted region contains all Gli3 coding sequences 3' to exon 9, which includes sequences encoding some, but not all, of the zinc finger domains. This deletion results in the expression of an abnormal transcript that fuses Gli3 sequences to an exon belonging to an apparent LTR/MaLR repetitive element. However, this transcript lacks the sequences required for normal GLI3 activity. |
When using the extra toes Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #000026 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wild-type for Gli3<Xt-J> |
Frozen Mouse Embryo | B6.C3-Gli3<Xt-J>/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.C3-Gli3<Xt-J>/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.C3-Gli3<Xt-J>/J Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | B6.C3-Gli3<Xt-J>/J Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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