This strain is homozygous for the retinal degeneration allele Pde6brd1. See article "Genetic Background Effects: Can Your Mice See?", JAX® NOTES Spring 2002, No. 485.
This inbred strain carries the wild-type allele of the flexed-tail mutation. (See FL/1ReJ, Stock No. 000023).
The initial FL/4Re inbred strain described in Coleman et al., 1968 was discontinued but restarted from the same FL/1Re segregating congenic line in 1970. This cryopreserved FL/4Re strain, which is also wildtype for f and Kit, and homozygous for the b polymorphism of Alad, was generated from FL/1Re mice at backcross generation N44 to N46, which were heterozygous for f, wildtype for Kit, and homozygous for the b polymorphism of Alad. Sibling intercrossing and selection for wildtype at the f locus yielded FL/4Re. This strain was also found to be homozygous for the Pde6brd1 allele. In 1979 embryos were generated for cryopreservation by sibling intercross at generation F27.
|Allele Name||retinal degeneration 1|
|Allele Synonym(s)||Pdebrd1; rd; rd1; rd-1; rodless retina|
|Gene Symbol and Name||Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide|
|Strain of Origin||various|
|General Note||The following inbred strains are known to be homozygous for Pde6b |
|Molecular Note||Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C-to-A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain, has been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested.|