The BXD set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes. The BXD strains are derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671) progenitor strains.Read More +
The BXD RI strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density.
The strain distribution pattern (SDP) for the BXD RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network.
The Jackson Laboratory live colony was a challenging breeder / very poor breeder. It exhibited a high incidence of non-productive matings and when productive, the litters were small [May 2021]. See our General Husbandry Tips.
The BXD set of RI strains was developed in the laboratory of Benjamin Taylor and was transferred to The Jackson Laboratory from Dr. Taylor's research colony upon his retirement. Of 42 BXD RI strains originally derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671), a number have become extinct over the years. The other BXD RI strains now being distributed are listed under "Related Recombinant Inbred Strains."
|Allele Synonym(s)||blue dilution; d; dv; Maltese dilution|
|Gene Symbol and Name||Myo5a, myosin VA|
|Strain of Origin||old mutant of the mouse fancy|
|Molecular Note||This mutation is the result of the integration of ecotropic murine leukemia virus Emv-3 into a noncoding region of the Myo5ad gene. Reversions of Myo5ad to wild-type are caused by excision of the virus leaving exactly one long terminal repeat in place.|
|Allele Name||a variant|
|Allele Type||Spontaneous (Not Applicable)|
|Gene Symbol and Name||B2m, beta-2 microglobulin|
|Strain of Origin||multiple strains|
|Molecular Note||The a variant is slightly slower running on SDS PAGE and was found to have an aspartic acid at amino acid position 85. This allele is found in A, BALB/c, LP and most other strains.|
When using the BXD18/TyJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000015 in your Materials and Methods section.