NOD/ShiLtJ-Sack1g^wly/J

Stock number: 004774
Product name: wooly
Research areas: Dermatology Research

Description

These mice carry a spontaneous deletion at the Sack1g (formerly Fam83g ) locus characterized by rough or matted appearance of their coats.

Detailed description

Mice develop curly hair by 4 weeks of age; whiskers are normal (straight). Giant hair follicles in anagen and a paucity of subdermal fat were found in histology of the skin at 5 weeks of age.

Development

The wooly mutation arose spontaneously in the NOD/LtJ production colony at The Jackson Laboratory in 2001 when that inbred was at F92. The wooly bearing strain has been maintained by sibling breeding and in 2004 reached F20.

Allele

Symbol: Sack1g^wly
Name: wooly
MGI accession ID: MGI:2668878
Generation method: Spontaneous
Marker symbol: Sack1g
Marker name: scaffolding CK1 anchoring protein G
Marker synonyms: 2310040C09Rik; FAM83G; PAWS1; wly
Chromosome: 11
Strain of origin: NOD/ShiLtJ
Molecular note: A 955 bp deletion removes part of intron 2 and the splice acceptor site at the beginning of exon 3. This results in incorrect splicing and a premature stop codon leading to a truncated protein. The deletion overlaps with intron 10 of Slc5a10 on the opposite strand but does not affect splicing of that gene.