JF1/Ms (Japanese Fancy Mouse) was derived from a fancy mouse stock, and has been identifed as belonging to species M. m. molossinus. JF1 is homozygous for the the piebald allele (Ednrbs).Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.Read More +
JF1/Ms (Japanese Fancy Mouse) was derived from a mouse stock purchased from a market in Denmark, and has been identifed as belonging to species M. m. molossinus. JF1 carries the piebald allele, a retroposon-like insertion in intron 1 of the endothelin receptor type B (Ednrb) gene, which results in a white coat with black spots and black eyes. The white areas of the coat are lacking in neural crest-derived melanocytes. In addition to alterations in coat color, JF1 mice exhibit a decreased amount of enteric innervation and neuronal density predominantly in the distal colon, but do not exhibit any of the megacolon symptoms often associated with mutations in Ednrb.Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.
Mice of a stock identified as a Japanese Fancy Mouse were purchased from a market in Denmark in 1987 and maintained by sibling inbreeding at the National Institute of Genetics, Mishima, Japan. In 1993, at generation F20, the established inbred strain was named JF1 (Japanese Fancy Mouse 1). Genetic analysis employing DNA microsatellite markers, biochemical markers used for typing mouse subspecies, and restriction fragment length polymorphism (RFLP) analysis of mitochondrial DNA led to the conclusion that JF1 is of the species Mus musculus molossinus (Koide et al. 1998). Mice of this strain were imported by The Jackson Laboratory in May 2000 from Dr Toshihiko Shiroishi.
|Allele Synonym(s)||pied spotting; s|
|Gene Symbol and Name||Ednrb, endothelin receptor type B|
|Gene Synonym(s)||ABCDS; AU022549; ET-B; ET-BR; ETB; ETB1; ETBR; ETR-b; ETRB; ETb; Ednra; Etb; HSCR; HSCR2; Sox10m1; WS4A; expressed sequence AU022549; piebald; s|
|Strain of Origin||old mutant of the mouse fancy|
|General Note||Also called piebald spotting. This is a very old mutation of the mouse fancy, and was described in the scientific literature as early as 1920 (J23183). Some piebalds in existing stocks may be of independent origin.|
|Molecular Note||This mutation is allelic to a targeted mutation for this gene. Homozygous mice produce approximately 25% of the normal levels of transcript from this allele. RT-PCR analysis demonstrated that no alterations in the coding sequence would result in any alteration of the amino acid sequence. A 5.5 kb retrotransposon-like element is found in intron 1. About 75% of the mRNA produced is an aberrant 6.5 kb form lacking exons 2-6 but containing exon 1. The remaining 25% of the mRNA formed is of normal, 4.4 kb, size.|
When using the JF1/MsJ mouse strain in a publication, please include JAX stock #003720 in your Materials and Methods section.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided,
their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of
each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders
are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in
order to provide the minimum number of animals, animals will ship within 25 weeks.
The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
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