NZW mice have a normal lifespan but do develop anti-DNA antibodies, high serum levels of retroviral gp70 antigen, and nephritis later in life. F1 hybrids of NZB/BlNJ and NZW/LacJ (Stock No. 100008) are widely used as a model for autoimmune disease resembling human systemic lupus erythematosus.Read More +
NZW mice have a normal lifespan but develop anti-DNA antibodies, high serum levels of retroviral gp70 antigen, and nephritis later in life. Although NZW mice have a large CD4+ T cell population, the proportion of FOXP3+ T regulatory cells (Treg) in the lymph nodes and spleen, but not thymus, is significantly decreased in comparison to several commonly used inbred strains (C57BL/6, BALB/c, NOD/ShiLtJ, CBA/J). F1 hybrids of NZB/BlNJ and NZW/LacJ (Stock No. 100008) are widely used as a model for autoimmune disease resembling human systemic lupus erythematosus.
The New Zealand White inbred strain (NZW) was produced by WH Hall in 1952 by inbreeding an outbred mouse colony and selection for white coat color. Dr. SE Bernstein at The Jackson Laboratory obtained NZW mice from the Laboratory Animal Center, Carshalton, Surrey (Lac) in 1981 and were subsequently transferred to the production colony. The current generation of inbreeding of NZW/LacJ mice is F48+.
|Gene Symbol and Name||Pctp, phosphatidylcholine transfer protein|
|Gene Synonym(s)||PC-TP; STARD2; StarD2; stARD2|
|Strain of Origin||NZO|
|Molecular Note||A G to A transition in exon 4 resulted in the arginine to histidine substitution at amino acid 120 in NZO, NZB/BINJ and NZW/LacJ strains. This mutation rendered the protein was inactive.|
When using the NZW mouse strain in a publication, please include JAX stock #001058 in your Materials and Methods section.
We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
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