The Jackson Laboratory’s Type 1 Diabetes Resource (T1DR), sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health, supports type 1 diabetes research by serving as an international repository for importation, curation, genotypic and phenotypic validation, cryopreservation and distribution of mouse stocks of value to the scientific community.
The T1DR currently holds over 250 genetically modified or congenic mouse stocks that are being used to dissect genetic and biologic features of T1D.
An added value of T1DR stocks is their ability to propel advances in related areas of science, including research in non-T1D autoimmunity and infectious diseases. Our staff provides information and technical assistance regarding selection and use of existing T1DR models, and will provide limited support for development of new models considered to be of high-value for the T1D community.
Over the next five years this major NIDDK-directed collaborative effort will have an increased emphasis on preclinical research model development. Expanded T1DR activities will be focused on development/refinement of mouse models expressing HLA or other molecules associated with disease susceptibility in patients, and on the use of these stocks to support engraftment with human immune cells or other tissues.