Characterized Cre strains for craniofacial research

We are characterizing cre strains useful for craniofacial research as part of a related resource, the JAX Cre Repository. a centralized, comprehensive set of well-characterized Cre Driver lines and related information resources.

Strains listed below have undergone in-depth characterization in our group, following the Cre Repository staining protocols.  Strains are listed alphabetically by promoter.

You can also visit creportal to search for Cre-expressing strains by promoter or site of activity, view detailed characterization of Cre activity including images, and get links to strains available in repositories.

Stock number(links to data sheet)

Strain name
(links to expression data)

Promoter (species)

Expected site of expression

Expression data thumbnail

018151

C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ

Krt17, keratin 17 (mouse)

Cre recombinase expression is driven by the endogenous keratin 17 (Krt17) promoter/enhancer elements

Krt17-cre Craniofacial Characterization

009388

B6;129S1-Osr2tm2(cre)Jian/J

Osr2, odd-skipped related 2 (Drosophila), mouse, laboratory

Cre recombinase activity is reported in developing palate and urogenital tract

Osr2-cre Craniofacial Characterization

018791

C57BL/6J-Tg(Trp63,-cre,-Cerulean)3Grsr/GrsrJ

Trp63, transformation related protein 63 (mouse)

Cre recombinase expression is driven by Trp63promoter/enhancer elements

p63-cre Craniofacial Characterization

018792

C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ

Trp63, transformation related protein 63 (mouse)

Cre recombinase expression is driven by Trp63promoter/enhancer elements

p63-cre Craniofacial Characterization

005584

B6.Cg-Tg(Prrx1-cre)1Cjt/J

Prrx1, paired related homeobox 1 (rat)

Cre recombinase activity is expected in early limb bud mesenchyme and in a subset of craniofacial mesenchyme, along with limited female germline expression

Prrx1-cre Craniofacial Characterization

018754

C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ

Tbx22T-box transcription factor 22 (mouse)

Cre recombinase expression is driven by Tbx22promoter/enhancer elements

Tbx22-cre Craniofacial Characterization

012719

STOCK Tgfb3tm1(cre)Vk/J

Tgfb3, transforming growth factor, beta 3 (mouse) 

Cre recombinase activity is expected in the heart, pharyngeal arches, otic vesicle, mid brain, limb buds, midline palatal epithelium, and whisker follicles during embryo and fetus development

Tgfb3-cre Craniofacial Characterization

009107

B6.Cg-Tg(Wnt1-GAL4)11Rth Tg(Wnt1-Cre)11Rth

Wnt1, wingless-related MMTV integration site 1 (mouse)

Cre recombinase activity is expected in embryonic neural tube, midbrain, caudal diencephalon, the mid-hindbrain junction, dorsal spinal cord, and neural crest cells

B6.Wnt1-cre Craniofacial Characterization