Rett syndrome results from mutations in MeCP2 that cause peripheral and central nervous system deficits, including a decreased sensitivity to pain, or hypoalgesia. A March 2016 study investigates the impact of mutations in MeCP2 on pain modulation and hypoalgesia in a mouse model of Rett syndrome.
“Optopatch” mice allow both optogenetic stimulation and simultaneous optical recording of electrical outputs in the same neuron. They are the latest addition to the mouse neurobiologist’s increasingly sophisticated optogenetic toolkit for optically mapping neural microcircuitry in intact tissue.
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive and fatal neurodegenerative disease that affects motor neurons. A January 2016 study published in Neurobiology of Disease describes a copper-based therapy that is quick-acting, safe, and effective in prolonging survival and even reversing disease signs in SODG93A ALS mice.
Dr. Burgess is studying Charcot-Marie Tooth syndrome, a genetic neurological disorder that causes damage to the peripheral nerves, the bundles of nerve cell fibers that connect the brain and spinal cord to muscles and sensory organs.