Rett syndrome results from mutations in MeCP2 that cause peripheral and central nervous system deficits, including a decreased sensitivity to pain, or hypoalgesia. A March 2016 study investigates the impact of mutations in MeCP2 on pain modulation and hypoalgesia in a mouse model of Rett syndrome.
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive and fatal neurodegenerative disease that affects motor neurons. A January 2016 study published in Neurobiology of Disease describes a copper-based therapy that is quick-acting, safe, and effective in prolonging survival and even reversing disease signs in SODG93A ALS mice.
Dr. Burgess is studying Charcot-Marie Tooth syndrome, a genetic neurological disorder that causes damage to the peripheral nerves, the bundles of nerve cell fibers that connect the brain and spinal cord to muscles and sensory organs.