Commonly used strains
Strains available only from the cytogenetics and Down syndrome models repository are listed in the table below. Stock numbers link to the strain datasheet, which includes information on aberration details, genotyping protocols, pricing, and links to useful references.
Down syndrome (DS) is caused by trisomy (3 copies) of some or all of human chromosome (Chr) 21. The majority of human Chr 21 genes are conserved in mouse Chr 16, with additional conserved regions on mouse Chrs 10 and 17. Our most widely used DS strains are the Ts65Dn models (symbolized as Ts(1716 )65Dn). Ts65Dn mice are trisomic for about two thirds of the human Chr 21 genes conserved in mouse Chr 16. Mice survive to adulthood and have many, though not all, of the features of people with DS. The Ts(1716)65Dn trisomy is available in two different strains (Stock Numbers 001924 and 005252).
Stock No. 001924 is the original trisomic Ts(1716)65Dn strain. However, Pde6brd1, the recessive retinal degeneration 1 mutation, is segregating in this stock; Pde6brd1 homozygotes are blind. Stock No. 005252 is an alternative strain, with a virtually identical genetic background except that it is wild-type for Pde6b, the result of continuous backcrossing to (C57BL/6JEiJ x C3Sn.BLiA-Pde6b+/DnJ)F1/J.
| Aberration | Stock # | Strain | Status |
|---|---|---|---|
| Ts(1716)65Dn | 005252 | B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ | Live colony |
| Ts(1716)65Dn | 001924 | B6EiC3Sn-a/A-Ts(1716)65Dn | Live colony |
| Rb(12.Ts171665Dn)2Cje | 004850 | B6EiC3Sn-Rb(12.Ts171665Dn)2Cje/CjeDnJ | Live colony |
| Dp(16Lipi-Zbtb21)1Yey | 013530 | B6.129S7-Dp(16Lipi-Zbtb21)1Yey/J | Live colony |
| Tc(HSA21)1Tyb | 0010801 | B6129S-Tc(HSA21)1TybEmcf/J | Live colony |
| N/A (control) | N/A | Wild-type from the same colonies as above | Live colony |
| N/A (mate for 001924 or 004850) | 001875 | B6EiC3SnF1/J | Live colony |
| N/A (mate for 005252) | 003647 | (C57BL/6JEiJ x C3Sn.BLiA-Pde6b+/DnJ)F1/J | Live colony |
| N/A (mate for 010801) | 012868 | B6129S8F1/J | Live colony |
| Ts(16C4-tel)1Cje | 004861 | B6EiC3Sn-Ts(1216C-tel)1Cje | Cryopreserved - Ready for Recovery |
| Rb(6.16)24Lub | 00885 | STOCK Rb(6.16)24Lub | Cryopreserved - Ready for Recovery |
| Rb(16.17)Bnr | 000615 | STOCK Rb(16.17)7Bnr | Cryopreserved - Ready for Recovery |
| Dp(10Prmt2-Pdxk)2Yey | 013529 | B6;129-Dp(10Prmt2-Pdxk)2Yey/J | Cryopreserved - Ready for Recovery |
| Dp(17Abcg1-Rrp1b)3Yey | 013531 | B6;129-Dp(17Abcg1-Rrp1b)3Yey/J | Cryopreserved - Ready for Recovery |
Featured publications
Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn. 2011. Mamm Genome 22(11-12):685-91.
Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down Syndrome. 2012. J Proteome Res 11(2):1251-63.
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