The Jackson Laboratory Cancer Center (JAXCC) is a National Cancer Institute-designated Cancer Center complemented by institutional education, resource and service initiatives that support cancer research world-wide. The NCI designated JAXCC comprises approximately 50 members with multidisciplinary expertise who are united in research aimed at understanding and targeting the genomic complexity of cancer.
The goal of the CGD is to evaluate the role of genome-wide organization in mammalian biology by developing detailed maps of genetic interactions that encompass allelic diversity, functional categories, gene expression, recombination hotspots, and phenotype associations.
Scientists around the world are working to generate a targeted knockout mutation for every gene in the mouse genome through the Knockout Mouse Project (KOMP) which is providing critical tools for understanding gene function and the genetic causes of human diseases.
Our goal is to focus our diverse expertise in biology and genomics on the problems and disorders associated with aging.
350 million people are affected by rare and orphan disease. The Rare and Orphan Disease Center conducts research to better treat these diseases.
Scientists in the JAX Center for Genetics of Fertility and Reproduction work on a variety of scientific problems of relevance to fertility and newborn health.
In this project we will create mice carrying the human pathogenic mutations identified by our collaborators. The mutations will be introduced onto both a standard, stable genetic background (C57BL/6J strain) and, to better emulate the human situation, onto a highly diverse genetic background (Diversity Outcross (DO) mice). The resulting new mouse models will be utilized to recapitulate and study key features of ALS pathophysiology. Successful models will be used to test drugs already approved by the FDA as well as to develop new drugs tailored to specific mechanisms of action and the impaired biological pathways of the mutated genes.
To understand disease mechanisms and ultimately develop effective therapies for AD, it is essential we apply state-of-the-art approaches to generate the next generation of more predictive animal models and make these models widely available to the AD research community.
The Center for Systems Neurogenetics of Addiction (CSNA) aims to identify the biological relationships between the stages and patterns of cocaine addiction and behaviors that predict drug abuse.
Alzheimer’s disease (AD) is a major cause of dementia, disability and death in the elderly. Despite recent advances in our understanding of basic biological mechanisms underlying AD, we do not yet know how to prevent AD or have an approved disease modifying intervention.
The center enables scientists to harness the full power of genomic technologies and computational strategies and use them to analyze the human genome to discover new and better ways of preventing and treating disease