Our Research Focus

The Jackson Laboratory offers a variety of genetic models for Alzheimer's disease (AD) research. AD models are made congenic on inbred strains, usually C57BL/6J, to stabilize the genetic background. Numerous novel strains carrying alleles of genes that have been identified as potential targets for AD therapies or AD risk genes by GWAS have been identified and imported for distribution.

Mouse models for Alzheimer's research

JAX® Mice for Alzheimer's Disease Research

Strains expressing APP and PSEN1 mutations

Strains expressing mutant APP

Inducible AD models

Strains expressing mutant tau (Mapt)

Strains with Presenilin mutations

Strains with Apoe mutations