HSA: integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure

Integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure

HSA is a flexible tool that can jointly analyze multiple contact maps from Hi-C experiments to infer the 3D chromatin structure of the genome.

Citation: Zou C, Zhang Y, Ouyang Z. (2016) HSA: integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure. Genome Biology, 17:40.

Visit HSA

Search MagazineAugust 14, 2018
Understanding our inheritence
To find out more about the complexities of inheritance, JAX spoke with author and New York Times columnist Carl Zimmer, who frequently writes about genetics and evolution. His new book, She Has Her Mother’s Laugh, tackles the vast concept of heredity – everything that living organisms pass on to future generations, and the means by which they do so.
Press ReleaseAugust 01, 2018
$2M NIH Grant to Study Genetic Mechanisms of Inherited Heart Muscle Disorders
Travis Hinson, M.D., has received more than $2 million from the National Institutes of Health National Heart, Lung, and Blood Institute to study the mechanisms responsible for a serious and often fatal heart condition.
- Cardiovascular
- Genetics and Genomics
Research HighlightJuly 30, 2018
Immune system 2.0: Can we re-engineer the human immune response?
JAX researchers have demonstrated the ability to target and disrupt specific genes and/or alter their expression levels, which has important implications for both immunology research and clinical treatments.
Research HighlightJuly 23, 2018
$2.4 million grant to JAX for strategies to extend healthy function of blood and immune systems during aging
The five-year grant enables studies exploring ways to boost the hematopoietic system for better regenerative capacity, immune cell function during aging.
- Aging
- Aging

Search MagazineAugust 08, 2018
Patient by patient: Finding cures for rare diseases
Four years ago as part of The Burgess Lab at The Jackson Laboratory, Kathy Morelli and a large team of collaborators took on the challenge of creating a cure for Caroline, a young girl who was battling an incurable disease called Charcot-Marie-Tooth.
Press ReleaseAugust 01, 2018
A RACIPE for success
New five-year, $2.2M outstanding investigator grant to Mingyang Lu will support systems biology algorithm approach.
Press ReleaseJuly 26, 2018
Alzheimer’s disease: The diet-gene connection
New $3.8M National Institute on Aging grant will fund JAX studies of hypothalamic dysfunction in Alzheimer’s.
- Alzheimer's Disease
- Neurodegenerative and Neuromuscular Diseases
Press ReleaseJuly 23, 2018
Eight new mouse models for Alzheimer’s disease available to researchers
Indiana University-Jackson Laboratory MODEL-AD Center addresses critical need for precision animal models for Alzheimer’s research.

HSA: integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure

Faculty & Staff

Zhengqing Ouyang, Ph.D.

Understanding our inheritence

$2M NIH Grant to Study Genetic Mechanisms of Inherited Heart Muscle Disorders

Immune system 2.0: Can we re-engineer the human immune response?

$2.4 million grant to JAX for strategies to extend healthy function of blood and immune systems during aging

Patient by patient: Finding cures for rare diseases

A RACIPE for success

Alzheimer’s disease: The diet-gene connection

Eight new mouse models for Alzheimer’s disease available to researchers