HSA: integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure

Integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure

HSA is a flexible tool that can jointly analyze multiple contact maps from Hi-C experiments to infer the 3D chromatin structure of the genome.

Citation: Zou C, Zhang Y, Ouyang Z. (2016) HSA: integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure. Genome Biology, 17:40.

Visit HSA

Research HighlightSeptember 20, 2019
An epigenetic eraser
The genome editing tool, Casilio, can be used to efficiently remove methyl groups from DNA and activate expression of methylation-silenced genes in experimental systems. Casilio was created by Jackson Laboratory Assistant Professor Albert Cheng.
Blog PostSeptember 16, 2019
Immunotherapy - implications for patients with mismatch repair deficient tumors
Presence of MSI-H in a dMMR tumor is correlated with the formation of novel small proteins that are recognized by T cells in the tumor microenvironment.
Blog PostSeptember 11, 2019
Revealing Antibody Characteristics with JAX Services
Antibody stability and half-life prediction in humans require appropriate in vivo experimental models. JAX Therapeutic Antibody Evaluation Services provides accurate and translationally-relevant pharmacokinetic (PK) data, allowing researchers worldwide to optimize their drug discovery pipeline.
Research HighlightAugust 21, 2019
The future of human and experimental genetics
This year, science luminaries came to Maine for an additional special symposium that celebrated the McKusick Short Course's 60th anniversary. The symposium title, “The Future of Human and Experimental Genetics,” foreshadowed the theme of the talks.

Search MagazineSeptember 19, 2019
The path to personalized treatments for rare diseases
The genetic study of rare diseases is giving us insight into how to examine and treat more common diseases, said JAX experts at a recent JAXtaposition event in Portland, ME.
- Rare Diseases
- Neurodegenerative and Neuromuscular Diseases
Press ReleaseSeptember 13, 2019
The microbiome and the nursing home
JAX, UConn researchers explore how patients’ microbiome, and risk of infection, change after time in a skilled nursing facility.
Search MagazineSeptember 04, 2019
Computing the etiology of cancer
What if, much like screening through genetic testing, we could learn how to better treat individual patients through their unique epigenetic markers? This is the question that Assistant Professor Sheng Li, Ph.D. tackles in her lab every day.
Research HighlightAugust 21, 2019
New JAX-UConn computational tool
Online analysis tool, Protein-RNA Association Strength (PRAS), free for academic researchers.
- Neuroscience
- Cancer