We develop and apply innovative genome technologies to understand chromatin structure and genome function pertinent to lineage specification and disease process.
Wei’s primary research focus is to develop genomic and sequencing technologies; apply them to interrogate genomic and epigenomic elements pertinent to genome function and biology. The goal is to uncover system biology networks in lineage specification processes and organism responses to stress and environment. We are interested to decipher regulatory networks of key functional modulators and their interactions with “non-coding functional elements” in mammalian cell genomes and their dynamics in developmental process. We believe that such knowledge will provide fundamental understanding in the role of genome organization in transcription regulation, differentiation and disease mechanisms.