The Wei Lab
We develop and apply innovative genome technologies to understand chromatin structure and genome function pertinent to lineage specification and disease process.
Principal Investigator
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Wei’s primary research focus is to develop genomic and sequencing technologies; apply them to interrogate genomic and epigenomic elements pertinent to genome function and biology. The goal is to uncover system biology networks in lineage specification processes and organism responses to stress and environment. We are interested to decipher regulatory networks of key functional modulators and their interactions with “non-coding functional elements” in mammalian cell genomes and their dynamics in developmental process. We believe that such knowledge will provide fundamental understanding in the role of genome organization in transcription regulation, differentiation and disease mechanisms.
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Research HighlightMay 23, 2023Two JAX researchers win Outstanding Paper Prize
Jennifer Sargent and Mark Warner have won a major publication award, highlighting their work with PDX. -
Blog PostMay 04, 2023Advancing cancer research with the latest therapies
Improving cancer patient outcomes depends on expanding our understanding of basic cancer biology as well as improving patient access to the latest therapies. -
Research HighlightApril 27, 2023Uncovering the genetic secrets behind human uniqueness
Ryan Tewhey is part of a research group that identified and characterized more than 10,000 human-specific Conserved Deletions (hCONDELs) enriched for brain functions. The findings will be important for further investigation of the evolutionary mechanisms that produce the traits that distinguish humans from other species. -
Research HighlightApril 11, 2023Churchill Lab performs multi-omics study on protein phosphorylation regulators
The Churchill lab performed an integrative multi-omics analysis of 58 genetically diverse Collaborative Cross strains to identify regulators of protein phosphorylation.
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Research HighlightMay 09, 2023Variability in the earliest stages of development
The processes enabling pluripotency at the very beginning of life are more different between mouse strains than you might expect. -
Blog PostMay 04, 2023JAX Genomic Education leads DNA Day 2023 celebrations
JAX Genomic Education joined the global celebration of all things genetics across JAX campuses, online, and in our communities. -
Research HighlightApril 25, 2023Unraveling exercise's impact on brain health
Erik Bloss has received a $3.9M R01 to study neurological changes in response to exercise and the role specific neurons in the brain. -
Research HighlightApril 05, 2023Exploring genetic diversity in mouse strains
Christine Beck led a team that explored mouse genome, and revealed details across 20 diverse inbred strains that will be critical for informing mouse-based genetics and genomics research moving forward.