Modeling Methods

Modeling microRNA-based regulation thumbnail

Cell-fate determination during Epithelial-Mesenchymal Transition (EMT) is regulated by a core circuit composed of two transcription factor families Snail and Zeb and two microRNA families miR34 and miR200.

Each of the microRNAs inhibits the level of the target protein by first binding to the corresponding mRNA and repressing the translation of the mRNA into protein.

We established a theoretical framework to model microRNA-based regulation and applied it to study the core regulatory circuit of EMT.