The Li Lab
Assessing the performance of next-generation sequencing techniques in accurate genome/epigenome/transcriptome profiling and understanding the clinical and functional role of epigenome heterogeneity in the cancer evolution.
Our research focus
My research interest is to understand the inner workings of cancer cells – the genetic and epigenetic heterogeneity that drive cancer initiation and progression. We utilize computational algorithms and multi-omics methodologies to identify and characterize the essential epigenetic lesions that guide cancer cells to evolve and escape anti-cancer therapy. The ultimate goal is to develop novel methods to predict and address tumor evolution.
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Research HighlightJanuary 12, 2021Few mutations, important difference in cancer cells
JAX Professor Sheng Li, Ph.D., presents a tool, epihet, that automates the epigenetic analysis of AML cells. epihet allows researchers to assess epigenetic differences between cells, identify genomic locations where the differences occur, and associate cellular epigenetic profiles with cancer-related biological function. -
Research HighlightJune 17, 2020New research reveals the role of epigenetic dysfunction in blood cancer
A new discovery by JAX cancer researcher Sheng Li points to the possibility of new lymphoma treatments that would restore the protective effect of TET2 in tumors where it has been mutated. -
Research HighlightOctober 11, 2018Stuck in a dangerous cycle
Paper provides important insight for B-cell lymphomagenesis from mouse models to human disease.
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Research HighlightOctober 20, 2020Connecting genetics with epigenetics in acute myeloid leukemia
Acute myeloid leukemia (AML) is an aggressive, difficult-to-treat cancer. Nonetheless, researchers have found that there are not as many genetic mutations associated with AML as with most other cancers. Aberrant epigenetic patterning, on the other hand, is emerging as a hallmark of AML. -
Search MagazineSeptember 04, 2019Computing the etiology of cancer
What if, much like screening through genetic testing, we could learn how to better treat individual patients through their unique epigenetic markers? This is the question that Assistant Professor Sheng Li, Ph.D. tackles in her lab every day.