The Li Lab

Assessing the performance of next-generation sequencing techniques in accurate genome/epigenome/transcriptome profiling and understanding the clinical and functional role of epigenome heterogeneity in the cancer evolution.

Our research focus

Algorithm development and integrative mining from high-throughput sequencing data to determine how somatic mutations alter the blood cancer epigenome and gene regulation in the context of aging, and lay the foundation for crafting future epigenetic therapeutic and preventative strategies.