Specific Aim 1: We will develop novel organismal, cellular, and computational models of cancer
Diverse models of cancer and novel technologies for investigating cancer biology are critical to support the basic research goals of JAXCC investigators. JAXCC members have distinguished records of developing models, methods, and resources in support of the research program that have had far-reaching impact on cancer research globally. We leverage these resources and model systems as platforms to engage in collaborations with clinical researchers. In ongoing and future work, we will:
Build and characterize a resource of Patient-Derived-Xenograft (PDX) models of human cancer for use of our own members and the larger scientific community. Further innovate in vivo models—including genetic humanization of immunodeficient mice to overcome their limitations for research into immuno-oncology. Expand our complementary in vitro models to support multiscale investigation into cancer biology, including studies on the functional consequences of genomic alterations
Develop and characterize genetically defined mouse populations and mutant strains for use in identifying mechanisms underlying the effects of genomic variation and genetic alterations on biological processes relevant to cancer. Work in this area includes novel approaches for efficient genetic engineering of the mouse genome, as well as use of genetically heterogeneous mouse populations such as the Collaborative Cross and Diversity Outbred mice and software resources for analysis of data generated using them.