Reciprocal interactions between accessory cells, their mediators, structural components of the extracellular matrix, and genetically altered neoplastic cells regulate all aspects of tumorigenicity and possible treatment resistance. Thus, JAXCC members investigate tumor and host microenvironments: the cancer cell intrinsic and extrinsic components of a malignant tumor. The vision is to integrate genetic alterations identified in Aim 2 with models developed in Aim 1 and with the unique expertise of JAXCC members involved in the work of Aim 3 to deconvolute these complex interactions. This in turn will enable the identification of novel candidate biomarkers as well as therapeutic targets.
In ongoing and future work, we will:
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