Publications

2019

Morelli KH, Griffin LB, Pyne NK, Wallace LM, Fowler AM, Oprescu SN, Takase R, Wei N, Meyer-Schuman R, Mellacheruvu D, Kitzman JO, Kocen SG, Hines TJ, Spaulding EL, Lupski JR, Nesvizhskii A, Mancias P, Butler IJ, Yang XL, Hou YM, Antonellis A, Harper SQ, Burgess RW. Allele-specific RNA interference prevents neuropathy in Charcot-Marie-Tooth disease type 2D mouse models. J Clin Invest. 2019 Sep 26. pii: 130600. doi: 10.1172/JCI130600. PMID: 31557132

Olinger E, Lake J, Sheehan S, Schiano G, Takata T, Tokonami N, Debaix H, Consolato F, Rampoldi L, Korstanje R, Devuyst O. Hepsin-mediated Processing of Uromodulin is Crucial for Salt-sensitivity and Thick Ascending Limb Homeostasis.  Sci Rep.  2019 Aug 23;9(1):12287. doi: 10.1038/s41598-019-48300-3. PMID: 31444371

Anderson CJ, Bredvik K, Burstein SR, Davis C, Meadows SM, Dash J, Case L, Milner TA, Kawamata H, Zuberi A, Piersigilli A, Lutz C, Manfredi G. ALS/FTD mutant CHCHD10 mice reveal a tissue-specific toxic gain-of-function and mitochondrial stress response. Acta Neuropathol. 2019 Jul;138(1):103-121. doi: 10.1007/s00401-019-01989-y. PMID: 30877432

Tadenev ALD, Burgess RW. Model validity for preclinical studies in precision medicine: precisely how precise do we need to be? Mamm Genome. 2019 Jun;30(5-6):111-122. doi: 10.1007/s00335-019-09798-0. [Epub ahead of print] PMID: 30953144

Zhou Y, Carmona S, Muhammad AKMG, Bell S, Landeros J, Vazquez M, Ho R, Franco A, Lu B, Dorn GW 2nd, Wang S, Lutz CM, Baloh RH. Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model. J Clin Invest. 2019 Mar 18;130:1756-1771. doi: 10.1172/JCI124194.

Bubier J, Hill D, Mukherjee G, Reynolds T, Baker EJ, Berger A, Emerson J, Blake JA, Chesler EJ.Curating gene sets: challenges and opportunities for integrative analysis. Database (Oxford). 2019 Jan 1;2019. pii: baz036. doi: 10.1093/database/baz036. PMID: 30888410

Forsberg MH, Foda B, Serreze DV, Chen YG. Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus. Sci Rep. 2019 Mar 13;9(1):4316. doi: 10.1038/s41598-019-40898-8. PMID:30867509

Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS. CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes. Front Immunol. 2019 Jan 31;10:99. doi: 10.3389/fimmu.2019.00099. eCollection 2019. PMID: 30766536

2018

Yuan SH, Hiramatsu N, Liu Q, Lenh D, Chan P, Chiang K, Koo EH, Kao AW, Litban I, Lin JHTauopathy -associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress. Hum Mol Genet. 2018 Nov 15;27(22):3951-3963. doi: 10.1093/hmg/ddy297. PMID: 30137327

Sheehan SM, Korstanje R. Automatic glomerular identification and quantification of histological phenotypes using image analysis and machine learning. AM J Physiol Renal Physiol. 2018 Sept 26. PMID: 30256126

Backer G, Eddy S, Sheehan SM, Takemon Y, Reznichenko A, Savage HS, Kretzler M, Korstanje R. FAR2 is Associated with Kidney Disease in Mice and Humans. Physiol Genomics. 2018 Aug 150(8):543-552. PMID: 29652635

Presa M, Racine JJ, Dwyer JR, Lamont DJ, Ratiu JJ, Sarsani VK, Chen YG, Geurts A, Schmitz I, Stearns T, Alloco J, Chapman HD, Serreze DV. A hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ Tcells in NOD Mice. J Immunol.

Schloss J Racine J.J., Riyasat  A, Racine J.J., Chapman H.D., Di Lorenzo T.P., Serreze D.V. HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression. J Immunol.

Racine J.J., Stewart I, Ratiu J.J., Christianson G, Lowell E, Helm K, Allocco J, Maser RS, Chen YG, Lutz CM, Roopenian D, Schloss J, KiLorenzo T.P., Serreze D.V. Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type I Diabetes Therapy Development. Diabetes. 2018 May;37:1-13. PMID: 29472249

2017

Wang Q, Racine JJ, Ratiu JJ, Wang S, Ettinger R, Wasserfall C, Atkinson MA, Serreze DV.  Transient BAFF Blockade Inhibits Type I Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy. J Immunol. 2017 Dec 1; 199(11):3757-3770. PMID: 29055002

Tian C, Gagnon LH, Longo-Guess C, Korstanje R, Sheehan SM, Ohlemiller KK, Schrader, AD, Lett JM, Johnson KR.  Hearing loss without overt metabolic acidosis in ATP6V1B1 deficient MRL mice, a new genetic model for non-syndromic deafness with enlarged vestibular aqueducts. Hum Mol Genet. 2017 Oct 1; 26(19): 3722-3735. PMID: 28934385

Korstanje R, Ryan JL, Savage HS, Lyons BL, Kane KG, Sukoff Rizzo SJ. Continuous Glucose Monitoring in Female NOD Mice Reveals Daily Rhythms and a Negative Correlation With Body Temperature. Endocrinology. 2017 Sept 1; 158 (9): 2707:2712. PMID: 28633442

Morelli KH, Seburn KL, Schroeder DG, Spaulding EL, Dionne LA, Cox GA, Burgess RW. Severity of Demyelinating and Axonal Neuropathy Mouse Models Is Modified by Genes Affecting Structure and Function of Peripheral Nodes. Cell Rep. 2017. 18(13):3178-3191. PMID: 28355569

Snyder EM, McCarty C, Mehalow A, Svenson KL, Murray SA, Korstanje R, Braun RE. APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo. RNA. 2017 April; 23(4):457-465. PMID: 5340909

Ratiu, J.J., Racine, J.J., Hasham, M.G., Wang, Q., Branca, J.A., Chapman, H.D. Zhu, J., Donghia, N., Phillip, V., Schott, W.H., Wasserfall, C., Atkinson, M.A., Mills, K.D. Leeth, C.M., Serreze, D.V. Genetic and small molecule disruption of the AID/RAD51 axis similarly protects NOD mice from type 1 diabetes through expansion of regulatory B-lymphocytes. J. Immunol. Epub, 2017 May 1. PMID: 28461573

Liu ET, Bolcun-Filas E, Grass DS, Lutz C, Murray S, Shultz L, Rosenthal N. Of mice and CRISPR: The post-CRISPR future of the mouse as a model system for the human condition. EMBO Rep. 2017 Feb;18(2):187-193. PMID: 28119373

Chiang WC, Chan P, Wissinger B, Vincent A, Skorczyk-Werner A, Krawczynski MR, Kaufman RJ, Tsang SH, Heon E, Kohl S, Lin JH. (2017). Achromatopsia mutations target sequential steps of ATF6 activation. Proc Natl Acad Sci USA. 2017 Jan 10;114(2):400-405. PMID: 28028229

2016

Leeth CM, Racine J, Chapman HD, Arpa B, Carrillo J, Carrascal J, Wang Q, Ratiu J, Egia-Mendikute L, Rosell-Mases E, Stratmann T, Verdaguer J, Serreze DV. B-lymphocytes expressing an immunoglobulin specificity recognizing the pancreatic ß-cell autoantigen peripherin are potent contributors to type 1 diabetes development in NOD mice. Diabetes. Mar 9. pii: db151606. [Epub ahead of print] PMID: 26961115

2015

Simecek, P., Churchill, G.A., Yang, H., Rowe, L. Herberg, D., Serreze, D.V., Leiter, E.H. and E. H. Leiter. (2015) Genetic analysis of substrain divergence in NOD mice. 3G Genes | Genomes | Genetics, 5:771. PMID: 25740934