Age-Related Macular Degeneration

New multifactorial and humanized models of Age-Related Macular Degeneration (AMD)

Project Leader: Patsy Nishina, Ph.D.

Co-Investigators: Stephen Tsang, M.D./Ph.D. (Columbia U Med Sch); Jonathan Lin, M.D./Ph.D. (UCSD)

The overall objective of this project is to create a humanized mouse model with a highly-penetrant, early AMD phenotype. The model will serve as a resource for dissecting pre-clinical defects and disease progression and allow us to segregate the role of different functional pathways to disease.