Comparison of Alzheimer's disease mouse models

Mouse Model (Stock Number)

Plaques

Tangles

Synaptic loss

Neuronal loss

Cognitive Deficit

"APP/PS1" B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax (MMRRC ID 034829-JAX-004462)
B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax (MMRRC ID 034832-JAX-005864)

Occasional Ab deposits in hippocampus and cortex at six months become abundant by nine months

No

Dystrophic neurites by four months

Not reported

Spatial learning deficit in MWM at 12 months

"5XFAD" B6SJL-Tg(APPSwFILon,PSEN1*M146L*L286V)6799Vas/Mmjax (MMRRC ID 034840-JAX-006554)
B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax (MMRRC ID 034848-JAX-008730)

In hippocampus and cortex at six to seven months

No

By nine months

Seen in cortical regions

Spatial learning deficit by four to five months

"3XTg-AD" B6; 129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax (MMRRC ID 034830-JAX-004807)

Observed at 6 months in frontal cortex

In hippocampus after six months, later in cortex

Not reported

Not detected

By four months

"J20" B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2J/Mmjax (MMRRC ID 034836-JAX-006293)

In hippocampus and cortex at six to eight months

No

By two to four months

in CA1 region at 3 months

Spatial learning deficit at six to seven months

"Tg-SwDI" C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax (MMRRC ID 034843-JAX-007027)

In hippocampus and cortex at three months

No

Not reported

Not reported

Learning and memory deficit by three months

"PS19" B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J (Stock No. 008169)

No

In neocortex, hippocampus, brain stem, spinal cord by six months

Yes

In hippocampusand entorhinal cortex by nine months

Spatial learning deficit in MWM at six months

"hTau" B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J (Stock No. 005491)

No

In neocortex and hippocampus by two months

Not reported

between 10-14 months

Spatial learning deficits by six months

"rTg4510" STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-MAPT*P301L)#Kha/J (Stock No. 024854)

No

In cortex by 4 months of age

by 8-9 months

by 6 months

Spatial learning deficit in MWM by 4 months of age

"TRE-hTau-A152T L1" C57BL/6-Tg(tetO-MAPT*A152T)L1Lms/J (Stock No. 028979)

No

No insoluble aggregates

Not reported

at 20 months in dentate gyrus and CA3

Spatial learning deficit in MWM by 17 months of age