The Jackson Laboratory Repository has focused on providing the most useful models for AD research for over a decade. These include disease models (e.g. those overexpressing APP, Presenilin, and/or tau), and strains useful for AD research (e.g. those expressing GFP, cre, or tTA in neuronal subsets). The repository also includes hundreds of knock-out models, many of which have been shown to exacerbate or ameliorate disease phenotypes when combined with AD models (e.g. Nos2, Meox2).
We continue to seek useful models for AD research. Strains can be submitted via a simple web form.