Genetic studies of late-onset Alzheimer's Disease have identified both common and rare variants associated with increased Alzheimer's Disease risk. We are working to develop novel mouse models expressing these variants either singly or in combinations to act as a sensitized background for development of Alzheimer's Disease -like phenotypes. We are also studying the effect of genetic background, the impact of environment (specifically diet and exercise) and the role of neuroinflammation in Alzheimer's Disease.
Novel models are being characterized in collaboration with the Mouse Neurobehavioral and Phenotyping Facility. We are also using transcriptomics and biomarkers to correlate novel models to patient populations.