Investigates gene regulatory networks in cellular processes using computational and statistical approaches.
Our laboratory investigates gene regulatory networks in cellular processes using computational and statistical approaches. We develop quantitative models and statistical learning methods for genomics. This involves analyzing "big data" from cutting-edge sequencing technologies and integrating various types of high-throughput genomic datasets. We have a particular interest in modeling genome regulation, including, but not limited to, transcription, noncoding RNA regulation and chromatin organization.
2013-Assistant Professor (affiliated), Department of Genetics and Developmental Biology, University of Connecticut School of Medicine, Farmington, CT
2013-Assistant Professor (affiliated), Department of Biomedical Engineering, University of Connecticut, Storrs, CT
2012-Assistant Professor, The Jackson Laboratory for Genomic Medicine, Farmington, CT
2013 - Eighth Annual Young Investigators, GenomeWeb
2009-2010 - Predoctoral Training Grant, California Institute for Regenerative Medicine and Stanford University
2004 - Innovation Award, Peking University
2003 -Choong Shin-Piaw Physical Science Forum Scholarship, Peking University
2002 - World’s Top 20 Certificate of Distinction, S*Star Bioinformatics Education
2002 - Diploma of Graduation with Highest Distinction, Beijing City
2002 -Diploma of Graduation with Highest Distinction, Peking University
Zhang Y, Ouyang Z, Zhao H , A statistical framework for data integration through graphical models with application to cancer genomics. Annals of Applied Statistics. 161-184, 2017.
Zhang Y, Linder MH, Shojaie A, Ouyang Z, Shen R, Baggerly KA, Baladandayuthapani V, Zhao H, Dissecting pathway disturbances using network topology and multi-platform genomics data, Statistics in Biosciences. First Online: 04 May 2017.
Hanley MP, Hahn MA, Li AX, Wu X, Lin J, Wang J, Choi AH, Ouyang Z, Fong Y, Pfeifer GP, Devers TJ, Rosenberg DW., Genome-wide DNA methylation profiling reveals cancer-associated changes within early colonic neoplasia, Oncogene. 2017
Chenchen Zou; Zhengqing Ouyang. Joint modeling of RNase footprint sequencing profiles for genome-wide inference of RNA structure. Nucleic Acids Research. 43(19):9187-97, 2015.
Zou C, Zhang Y, Ouyang Z. HSA: integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure. Genome Biology. 17:40, 2016.
Yue Wan, Kun Qu, Qiangfeng Cliff Zhang,1 Ryan A. Flynn, Ohad Manor, Zhengqing Ouyang, Jiajing Zhang, Robert C. Spitale, Michael P. Snyder, Eran Segal, and Howard Y. Chang. Landscape and variation of RNA secondary structure across the human transcriptome. Nature. 505(7485): 706–709, 2014.
Ouyang Z, Snyder MP, Chang HY. SeqFold: genome-scale reconstruction of RNA secondary structure integrating high-throughput sequencing data. Genome Res. 23(2):377-87, 2013.
Zhengqing Ouyang, Qing Zhou, and Wing Hung Wong. ChIP-Seq of transcription factors predicts absolute and differential gene expression in embryonic stem cells. Proc Natl Acad Sci U S A. 106(51): 21521–21526, 2009.
Ouyang Z, Zheng GX, Chang HY. Noncoding RNA landmarks of pluripotency and reprogramming. Cell Stem Cell. 7(6): 649–650, 2010.
Alzheimer’s disease is a degenerative brain disease that leads to cognitive decline, dementia and ultimately death, mostly in the elderly.
JAX researchers say structural deterioration associated with old age can be prevented by long-term aerobic exercise starting in mid-life.
New research reported in Nature Medicine (Smith et al., 2015) demonstrates that β2-microglobulin (β2M), a subunit of the major histocompatibility complex class I (MHC I) molecule, increases in the blood during aging and causes diminished cognitive function and neurogenesis. The aging-related defects caused by β2M appear reversible, implicating this molecule as a potential therapeutic target to mitigate a wide range of neurodegenerative diseases.
In addition to sequence, three-dimensional (3D) genome structure contributes to vital functions, including transcriptional regulation, DNA replication and DNA methylation.
JAX is looking for postdocs to join its researchers in using the power of human genomics and modern mouse genetics to understand the complex basis of Alzheimer’s disease.
Assistant Professor Zhengqing Ouyang, Ph.D., received a one-year, $100,000 Research Starter Grant in Informatics from the Pharmaceutical Research and Manufacturers of America (PhRMA) Foundation.
Caveolin 1- (Cav1) deficiency accelerates neurodegeneration in aging mice, suggesting that Cav1-stabilizing therapies may protect neurons against injury or neurodegenerative diseases, such as Alzheimer’s.
Advance your research in genetics by harnessing the power of the mouse! This new graduate-level advanced genetics course will provide a...
This new intensive hands-on JAX course will provide scientists with the skills and knowledge required for rigorous design, execution,...
This workshop provides training in the use of genetically defined laboratory mice as tools for asking questions about gene function and the...
New research reported in Nature Medicine (Smith et al., 2015) demonstrates that β2-microglobulin (β2M), a subunit of the major...
Caveolin 1- (Cav1) deficiency accelerates neurodegeneration in aging mice, suggesting that Cav1-stabilizing therapies may protect neurons...
Parkinson's disease is a neurodegenerative disorder that affects movement. The Jackson Laboratory distributes Parkinson’s disease models...
Utilizes spontaneous and CRISPR/Cas9 generated mouse lines along with primary cell culture models to look at the molecular intersection...
JAX researchers say structural deterioration associated with old age can be prevented by long-term aerobic exercise starting...
JAX is looking for postdocs to join its researchers in using the power of human genomics and modern mouse genetics to understand the...
Alzheimer’s disease is a degenerative brain disease that leads to cognitive decline, dementia and ultimately death, mostly...
Researches the molecular pathways of human degenerative muscle diseases.
Researches the molecules and pathways important to the development and physiology of the ear, with a focus on hearing loss...
Works on the Mouse Phenome Project, collecting phenotype (measurement) data and disseminating them from the Mouse Phenome...
My research interests are focused on the development of methods that facilitate research effectiveness and allow for novel experimental...
Researches glaucoma and other neurodegenerative disease, developing new microelectronic devices to monitor/treat disease.
Models genome regulation using computational and statistical methods.