Investigates gene regulatory networks in cellular processes using computational and statistical approaches.
Our laboratory investigates gene regulatory networks in cellular processes using computational and statistical approaches. We develop quantitative models and statistical learning methods for genomics. This involves analyzing "big data" from cutting-edge sequencing technologies and integrating various types of high-throughput genomic datasets. We have a particular interest in modeling genome regulation, including, but not limited to, transcription, noncoding RNA regulation and chromatin organization.
2013-Assistant Professor (affiliated), Department of Genetics and Developmental Biology, University of Connecticut School of Medicine, Farmington, CT
2013-Assistant Professor (affiliated), Department of Biomedical Engineering, University of Connecticut, Storrs, CT
2012-Assistant Professor, The Jackson Laboratory for Genomic Medicine, Farmington, CT
2013 - Eighth Annual Young Investigators, GenomeWeb
2009-2010 - Predoctoral Training Grant, California Institute for Regenerative Medicine and Stanford University
2004 - Innovation Award, Peking University
2003 -Choong Shin-Piaw Physical Science Forum Scholarship, Peking University
2002 - World’s Top 20 Certificate of Distinction, S*Star Bioinformatics Education
2002 - Diploma of Graduation with Highest Distinction, Beijing City
2002 -Diploma of Graduation with Highest Distinction, Peking University
Talks at the Human Genome Meeting by two prominent researchers of genome evolution showed how investigations of our genomic history might provide clues that contribute to tomorrow’s cures.
Alzheimer’s disease is a degenerative brain disease that leads to cognitive decline, dementia and ultimately death, mostly in the elderly.
Assistant Professor Zhengqing Ouyang, Ph.D., received a one-year, $100,000 Research Starter Grant in Informatics from the Pharmaceutical Research and Manufacturers of America (PhRMA) Foundation.
Caveolin 1- (Cav1) deficiency accelerates neurodegeneration in aging mice, suggesting that Cav1-stabilizing therapies may protect neurons against injury or neurodegenerative diseases, such as Alzheimer’s.
JAX is looking for postdocs to join its researchers in using the power of human genomics and modern mouse genetics to understand the complex basis of Alzheimer’s disease.
JAX researchers say structural deterioration associated with old age can be prevented by long-term aerobic exercise starting in mid-life.
New research reported in Nature Medicine (Smith et al., 2015) demonstrates that β2-microglobulin (β2M), a subunit of the major histocompatibility complex class I (MHC I) molecule, increases in the blood during aging and causes diminished cognitive function and neurogenesis. The aging-related defects caused by β2M appear reversible, implicating this molecule as a potential therapeutic target to mitigate a wide range of neurodegenerative diseases.
Zou C, Zhang Y, Ouyang Z. (2016) HSA: integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure. Genome Biology. 17:40.
Yue Wan, Kun Qu, Qiangfeng Cliff Zhang,1 Ryan A. Flynn, Ohad Manor, Zhengqing Ouyang, Jiajing Zhang, Robert C. Spitale, Michael P. Snyder, Eran Segal, and Howard Y. Chang. Landscape and variation of RNA secondary structure across the human transcriptome. Nature. 2014 Jan 30; 505(7485): 706–709.
Ouyang Z, Snyder MP, Chang HY. SeqFold: genome-scale reconstruction of RNA secondary structure integrating high-throughput sequencing data. Genome Res. 2013 Feb;23(2):377-87.
Ouyang Z, Zheng GX, Chang HY. Noncoding RNA landmarks of pluripotency and reprogramming. Cell Stem Cell. 2010 Dec 3; 7(6): 649–650.
Zhengqing Ouyang, Qing Zhou, and Wing Hung Wong. ChIP-Seq of transcription factors predicts absolute and differential gene expression in embryonic stem cells. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51): 21521–21526.
Advance your research in genetics by harnessing the power of the mouse! This new graduate-level advanced genetics course will provide a...
This new intensive hands-on JAX course will provide scientists with the skills and knowledge required for rigorous design, execution,...
This workshop provides training in the use of genetically defined laboratory mice as tools for asking questions about gene function and the...
Talks at the Human Genome Meeting by two prominent researchers of genome evolution showed how investigations of our genomic history might...
New research reported in Nature Medicine (Smith et al., 2015) demonstrates that β2-microglobulin (β2M), a subunit of the major...
Caveolin 1- (Cav1) deficiency accelerates neurodegeneration in aging mice, suggesting that Cav1-stabilizing therapies may protect neurons...
Parkinson's disease is a neurodegenerative disorder that affects movement. The Jackson Laboratory distributes Parkinson’s disease models...
Conducts research utilizing TALEN and CRISPR/Cas9 generated transgenic mice to probe the functional role of other U2 snRNAs, previously...
JAX is looking for postdocs to join its researchers in using the power of human genomics and modern mouse genetics to understand the...
Alzheimer’s disease is a degenerative brain disease that leads to cognitive decline, dementia and ultimately death, mostly...
Researches the molecular pathways of human degenerative muscle diseases.
JAX researchers say structural deterioration associated with old age can be prevented by long-term aerobic exercise starting...
A mouse model of spinal muscular atrophy developed at The Jackson Laboratory lay the foundation for the successful clinical...
Models genome regulation using computational and statistical methods.
Researches the molecules and pathways important to the development and physiology of the ear, with a focus on hearing loss...
Researches glaucoma and other neurodegenerative disease, developing new microelectronic devices to monitor/treat disease.