Bar Harbor, ME
Researches glaucoma and other neurodegenerative disease, developing new microelectronic devices to monitor/treat disease.
We use genetics, genomics, cell biology and physiology to understand the fundamental biologic processes that cause disease. We focus on IOP regulation and neurodegeneration in glaucoma, but also have experience studying other diseases including, anterior segment dysgenesis, uveitis, iris atrophy, pigment dispersion, nanophthalmos, macular degeneration, and axonopathies. As necessary, we provide new knowledge by innovating and developing new research tools as well as by fostering collaborations. In collaboration with biomedical and electrical engineers, we are developing new microelectronic devices to enhance research and monitor/treat disease. Major goals are to provide new understanding of disease mechanisms and new devices to improve patient care and treatments.
Adv: Dr. Charles R. Scriver and Dr. Rima Rozen
University College Cardiff
B.Sc., zoology and genetics
Adv: Dr. Jerome Den Hollander
Tufts University School of Medicine
Graduate Professor, Sackler School of Graduate Biomedical Sciences
Clinical Collaborator, Center for Implantable Devices
University of Maine, Orono
Cooperating Professor, Functional Genomics
The University of Maine
Howard Hughes Medical Institute
Assistant Investigator, Associate Investigator and then Investigator (since 2005)
Tufts University School of Medicine
Research Assistant Professor, Ophthalmology,
The Jackson Laboratory
Associate Staff, Staff and then Senior Staff Scientist/Professor (since 2006, institutional title change to professor system in 2008)
University of North Carolina
Adv: Dr. Oliver Smithies, Excellence Professor of Pathology
Lewis Rudin Glaucoma Prize
Bressler Vision Science Award
Alcon Research Institute Award
Global Glaucoma Award from the Association of International Glaucoma Societies
Lewis Rudin Glaucoma Prize
Cogan Award from the Association for Research in Vision & Ophthalmology
Ruth Salta Junior Investigator Achievement Award
Becton Dickinson Young Investigator Fellowship
Canadian Society of Clinical Investigation Student Award
Williams PA, Harder JM, Foxworth NE, Cochran KE, Philip VM, Porciatti V, Smithies O, John SWM. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science. 355(6326):756-760. 2017.
Harder JM, Braine CE, Williams PA, Zhu X, MacNicoll KH, Sousa GL, Buchanan RA, Smith RS, Libby RT, Howell GR*, John SWM. Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective. Proc Natl Acad Sci U S A 114(19):E3839-E3848. 2017.
Williams PA, Harder JM, Foxworth NE, Cardoza BH, Cochran KE, John SWM. Nicotinamide and WLDS act together to prevent neurodegeneration in glaucoma. Front Neurosci 11:232. 2017.
Kizhatil K, Ryan M, Marchant J, Henrich S, John SWM. Schlemm’s canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process. PloS Biol 12(7):e1001912. 2014.
Kizhatil K, Chlebowski A, Tolman N, Freeburg N, Shaw N, Ryan M, Marchant J, John SWM. An in vitro perfusion system to enhance outflow studies in mouse eyes. Invest Ophthalmol Vis Sci 1;57(13):5207-5215. 2016.
An immune response triggered by high pressure in the eye occurs early in glaucoma and has a protective effect on retinal cells, a Jackson Laboratory (JAX) research team led by Professor and Howard Hughes Medical Institute Investigator Simon W.M. John, Ph.D., reports in the Proceedings of the National Academy of Sciences.
New research shows that simply adding vitamin B3 to the drinking water of mice predisposed to glaucoma can prevent the debilitating eye disease.
Schlemm’s canal is critical in maintaining proper fluid flow from the eye. Researchers are trying to better understand its role in ocular health and disease.
Post-doctoral researchers, such as Steven Munger--a statistical geneticist--play an important role in the advancement of research at The Jackson Laboratory and beyond.
New research shows that combination therapy of vitamin B3 and a fusion gene variant called the Wallerian degeneration slow allele prevented glaucoma in 94 percent of tested eyes.
JAX research provides insight into the role of the western diet in Alzheimer’s disease.
Simon John leads a smooth-running team effort to investigate glaucoma's causes and find targets for therapy.
By using new scientific methods to scrutinize genetic pathways, researchers are now able to detect early signs of glaucoma.
This new intensive hands-on JAX course will provide scientists with the skills and knowledge required for rigorous design, execution,...
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Uses advanced methods to research glaucoma and other neurodegenerative diseases.
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Models genome regulation using computational and statistical methods.
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Serves as a centralized resource for mouse models and tools that have been validated for use in preclinical studies of peripheral...
NSG™ variants are the most highly immunodeficient mice and the models of choice for cancer xenograft modeling, stem cell...
International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data.