Develops novel genomic technologies and computational algorithms to study molecular mechanisms of RNA biology, including RNA modifications, RNA-protein interactions and messenger RNA (mRNA) processing.
As an indispensible molecule of living organisms, RNA plays key roles in various biological processes at both intra- and inter-cellular levels. My overall research interest is to study RNA from birth to death during organism neurological development, and its malfunctions in diseases for effective therapies in clinics. My research has been always implementing inter-discipline approaches, including bioinformatics (genomics), biochemistry, innovative biotechnologies, genetics and molecular biology.
Ke, S.*, Anquetil, V.*, Rojas-Zamalloa J.*, Maity, A., Yang, A., Arias, M.A., Kalachikov, S., Ju, J. & Chasin L.A. Saturation mutagenesis reveals manifold determinants of exon definition, Genome Research 2018 10.1101/gr.219683.116 (* Joint-first author)