Understands molecular mechanisms of tumorigenesis and drug resistance using cancer clinical genomic data.Visit The Chuang Lab
I have been interested in understanding genetic origins and molecular evolution of life and human diseases, and finding cures for various human diseases particularly cancer and infectious diseases. My current focus is studying cancer clinical genomics from the perspectives of molecular evolution and population genetics. My goal is to understand the process of tumorigenesis, metastasis and drug resistance, and to identify markers for cancer diagnosis, prognosis, and therapeutics.
Zhao ZM, Wang J, Ugwuowo UC, Wang L, and Townsend JP. Primary hepatic neuroendocrine carcinoma: report of two cases. BMC Clinical Pathology. 2018.
Cannataro VL, Gaffney SG, Stender C, Zhao ZM, Philips M, Greenstein AE, Townsend JP. Heterogeneity and mutation in KRAS and associated oncogenes: evaluating the potential for the evolution of resistance to targeting of KRAS G12C. Oncogene. 2018
Zhao ZM, Campbell MC, Li N, Lee DSW, Zhang Z, Townsend JP, Detection of regional variation in selection intensity within protein-coding genes using DNA sequence polymorphism and divergence, Molecular Biology and Evolution. 2017