Yair Dorsett

Yair Dorsett, Ph.D.

Associate Research Scientist

Farmington, CT

My research interests are focused on the development of methods that facilitate research effectiveness and allow for novel experimental observations. I am also investigating how the gut microbiome influences the development of autoimmune diseases, specifically multiple sclerosis.

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Education and experience

Education:

  • 2000, B.A. Biology. The Colorado College, Colorado Springs, Colorado
  • 2002, M.A. Biology. New York University, New York, New York
  • 2008, Ph.D. The Rockefeller University, New York, New York. Field: Cancer Immunology. Advisor: Michel Nussenzweig

Research Experience:

  • Summer 2000 – Postgraduate Research, Rockefeller University, New York. PI: Michel Nussenzweig. Role of dendritic cells in immune response - in vivo targeting of antigen to dendritic cells by recombinant antibody specific for the DEC receptor.
  • 2001-2002 – Masters Research, New York University, Biology Department. PI: Gloria Corruzzi. Identification of cis promoter elements that react to light, nitrogen or carbon in plants by DNA sequence and microarray analysis of genes that respond to these stimuli.
  • 2002 – 2005 - Graduate Research, Rockefeller University, New York. PI: Thomas Tuschl. Research: Mechanisms of RNA interference in mammalian germ cells and Drosophila.
  • 2005 – 2008 - Ph.D. Thesis Research, Rockefeller University, New York. PI: Michel Nussenzweig. Role of AID and microRNA-155 in c-myc-IgH translocations.
  • 2008 – 2009 - Postdoctoral Research, Rockefeller University, New York, PI: Michel Nussenzweig. Role of microRNA-155 in regulation of AID and IgB to IgH  and c-myc to IgH translocations.
  • 2009 –  2015, Postdoctoral Fellow and Staff Scientist, Washington University School of Medicine. PI: Barry Sleckman. Role of H2AX and 53BP1 in non-homologous end joining and development of a novel assay for the identification of DNA end structures at single nucleotide resolution.
  • 2015 – present, Associate Research Scientist, The Jackson Laboratory for Genomic Medicine. PI: George M. Weinstock. Development of wet lab methods for defining the microbiome and investigation of how the microbiome influences the development of Multiple Sclerosis.