Petko Petkov, Sr. Research Scientist

Petko Petkov, Ph.D.

Senior Research Scientist

Bar Harbor, ME

Investigating genetics/mechanisms of recombination and role of PRDM9.

Grants, honors and accomplishments

Ongoing Research Support 

5 P50 GM076468-07 Churchill (PI)
Center for Genome Dynamics - Project B: Systems Genetics of Meiotic Recombination
The goal of this project is to identify epistatic genes that interact in networks to control the location and activity of recombination hotspots. Role: Project Leader 

2 R01 GM078452-06A1 Petkov (PI)
Sex-Specific Regulation of Meiotic Recombination Hotspots
The goal of this project is to determine the factors regulating sex specificity of meiotic recombination, both in its regional distribution along the chromosomes and the activity of sex-specific recombination hotspots. Role: Principal Investigator 

TJL-CCSG-Pilot-PMP01 Petkov (PI)
The Jackson Laboratory Cancer Center
The Jackson Laboratory Cancer Center, 2012-2013 Pilot Feasibility Studies - Does PDRM9 Play a Role in Cancer?
The goal of this project is to determine whether the expression of Prdm9 influence the incidence of tumor formation and progression in Apc+/- mice. Role: Principal Investigator 

6 TJL DIF FY14 GWC Collab Carter (PI) 
05/01/14 - 04/30/16
The Jackson Laboratory Director’s Innovation Fund Genetics of Molecular Epigenetics
The goal of this project is to understand the consequences of genetic variation on genomewide transcript regulation Role: Joint PI 

Completed Research Support 

5 R01 GM078452-05 Petkov (PI)
Chromosome-wide Mapping of Recombinational Activity
The goal of this project is to achieve understanding of the principles that determine the existence and activity of recombinational hot spots across the genome. Role: Principal Investigator 

3 R01 GM083408-02S1Z Paigen (PI)
Transacting Genes Regulating Recombination Hotspot Activities - ARRA Administrative Supplement
The aim of this project is to search for genes suppressing and modulating recombination activity Role: Co-Investigator 

5 P50 GM076468-05 Churchill (PI)
Genome Dynamics: Evolution, Organization and Function - Project 5: Chromosome-wide Mapping of Recombinational Activity
The goal of this project is to create high-resolution genetic maps of Chr 11 in six mouse crosses and study how genetic background, sex and imprinting affect hotspot positioning and usage. This study will provide the necessary information to start a comprehensive mapping of genes regulating recombination activity. Role: Project Leader 

5 P50 GM076468-05 Churchill (PI)
Genome Dynamics: Evolution, Organization and Function - Core 3: Molecular Biology
The main task of this core is to provide high-quality DNA and RNA samples for Projects 1, 3 and 5, and to perform expression studies using Affymetrix microarrays and real-time PCR.. Role: Core Leader 

2 P40 RR016049-06A1 Donahue (PI)
Special Mouse Strains Resource
The major goal of this project is to maintain, characterize and distribute recombinant inbred and consomic strains of mice. Role: Research Scientist 

5 R21 AR055181-02 Petkov (PI)
Search for Genes Involved in Arthritis Pathogenesis
The specific aims of this project are: (1) Map the region on chromosome 6 responsible for arthritis resistance using a backcross between B6-Chr6PWD and B6, and select candidate genes. (2) Evaluate arthritis susceptibility and clinical parameters of arthritis development using the entire set (n=28) of ChrNPWD consomics and the serum-transfer model of arthritis. 7 Role: Principal Investigator 

5 R01 GM078643-03 Paigen (PI)
Genomic Organization of Recombination Hot Spots
The major goal of this grant is obtain a detailed map at one Kb resolution of all recombinational hotspots, including their sex and haplotype specificity, for five different five Mb regions chosen for their particular biological interest on separate chromosomes using 6000 meioses. Role: Co-Investigator 

AG-SS-1631-06 Paigen (PI)
Ellison Medical Foundation New Genetic Strategies in the Study of Aging
The goal of this project is the development of new genetic strategies in the study of human aging using RNAi directed mutagenesis in somatic cell cultures to identify previously unknown genes participating in the aging process. Role: Co-Principal Investigator