Researches genetic recombination, exploring the mechanisms that determine its location and DNA binding specificity.
DNA carries out its functions by serving as the substrate for three biological processes: replication, genetic recombination and gene transcription. Our group is presently concerned with genetic recombination, exploring the mechanisms that determine the location of genetic recombination sites and the complex rules of DNA binding specificity. We are identifying and characterizing the components of a novel regulatory system controlling the location of recombination hotspots, the sites of genetic recombination, and the extent to which binding protein variants, partner protein interactions, and the influences of sex affect recombination.
LL.D (hon) Bowdoin College
2008 - Fulbright Senior Specialists Award
Baker CL, Walker M, Kajita S, Petkov PM, Paigen K. 2014. PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration. Genome Res. 2014 24(5):724-32.